Thunder Bay Regional Health Sciences Center, Thunder Bay, Ontario, Canada.
Resuscitation. 2013 Jan;84(1):13-20. doi: 10.1016/j.resuscitation.2012.08.331. Epub 2012 Sep 4.
The best performing early warning score is Vitalpac™ Early Warning Score (ViEWS). However, it is not known how often, to what extent and over what time frame any early warning scores change, and what the implications of these changes are.
Thunder Bay Regional Health Sciences Center, Ontario, Canada.
The changes in the first three complete sets of the six variables required to retrospectively calculate the abbreviated version of ViEWS (that did not include mental status) after admission to hospital of 18,853 acutely ill medical patients, and their relationship to subsequent in-hospital mortality were examined.
In the 10.4 SD 20.1 (median 5.0) hours between admission and the second recording the score changed in only 5.9% of patients and these changes were of no prognostic value. By the time of the third recording 34.9 SD 21.7 (median 30.0) hours after admission a change in score was clearly associated with a corresponding change in in-hospital mortality (e.g. for patients with an initial score of 5 an increase between the first and third recording of ≥4 points was associated with an increased mortality (OR 6.5 95% CI 2.3-15.9, p<0.00001), whereas a reduction of ≤-4 points was associated with a reduced mortality (OR 0.4 95% CI 0.2-0.9, p 0.03)).
After a median interval of 30 h both the initial abbreviated ViEWS recording and subsequent changes in it both predict clinical outcome. It remains to be determined what interventions during this time frame will improve patient outcomes.
表现最佳的早期预警评分是 Vitalpac™早期预警评分(ViEWS)。然而,目前尚不清楚任何早期预警评分变化的频率、程度和时间范围,以及这些变化的意义。
加拿大安大略省 Thunder Bay 地区健康科学中心。
对 18853 名急性病医疗患者入院后前三个完整的六变量集(不包括神志状态)进行回顾性计算 ViEWS 简化版,记录这些变量集的变化,并分析其与住院期间死亡率的关系。
在入院至第二次记录的 10.4 个标准差 20.1 小时(中位数 5.0)期间,只有 5.9%的患者评分发生变化,这些变化没有预后价值。到入院后 34.9 个标准差 21.7 小时(中位数 30.0)的第三次记录时,评分的变化与住院期间死亡率的变化明显相关(例如,初始评分为 5 的患者,在第一次和第三次记录之间的评分增加≥4 分与死亡率增加相关(比值比 6.5,95%置信区间 2.3-15.9,p<0.00001),而减少≤-4 分与死亡率降低相关(比值比 0.4,95%置信区间 0.2-0.9,p<0.03))。
在中位数间隔 30 小时后,简化版的初始 ViEWS 记录及其后续变化都可以预测临床结局。在这段时间内进行哪些干预措施将改善患者结局,还有待确定。