Teeuwen P H E, de Geus-Oei L F, Hendriks T, van Goor H, Bremers A J A, Oyen W J G, Bleichrodt R P
Department of Surgery, Division of abdominal Surgery and Surgical Oncology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Nuklearmedizin. 2012;51(6):252-6. doi: 10.3413/Nukmed-0493-12-04. Epub 2012 Sep 7.
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a known method to diagnose inflammatory processes and thus may be a promising imaging technique to detect anastomotic bowel leak. The aim of this study was to assess postoperative FDG uptake in colorectal anastomosis in patients without suspicion of active infection or anastomotic leakage.
PATIENTS, METHODS: Design of a prospective observational pilot study in order to assess normal FDG uptake in the patient anastomosis after colorectal surgery. Patients that underwent colorectal surgery with primary anastomosis received FDG-PET of the abdomen, 2-6 days postoperatively.
35 patients met the inclusion criteria. Three patients were not scanned for various reasons. Of the remaining 32 patients, one demonstrated an increased uptake of FDG at the site of the anastomosis. In the other 31 patients FDG uptake was negligible (n = 17) or scored as physiological (n = 14). None of the scanned patients developed a clinical relevant anastomotic leakage within the first 30 days after surgery.
The present study shows that FDG uptake in colorectal anastomosis remains low within the first six days after surgery in patients without anastomotic leakage. Therefore, FDG-PET might be useful to investigate further as a tool to detect anastomotic leakage in an the early postoperative phase.
18F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）是一种已知的诊断炎症过程的方法，因此可能是检测肠吻合口漏的一种有前景的成像技术。本研究的目的是评估无活动性感染或吻合口漏怀疑的患者结直肠吻合术后的FDG摄取情况。
患者、方法：设计一项前瞻性观察性试点研究，以评估结直肠手术后患者吻合口的正常FDG摄取情况。接受结直肠手术并进行一期吻合的患者在术后2-6天接受腹部FDG-PET检查。
35例患者符合纳入标准。3例患者因各种原因未进行扫描。在其余32例患者中，1例在吻合口部位显示FDG摄取增加。在其他31例患者中，FDG摄取可忽略不计（n = 17）或评为生理性摄取（n = 14）。所有接受扫描的患者在术后30天内均未发生临床相关的吻合口漏。
本研究表明，在无吻合口漏的患者中，术后头六天内结直肠吻合口的FDG摄取仍然较低。因此，FDG-PET作为术后早期检测吻合口漏的工具，可能值得进一步研究。
