Clinical Epidemiology and Outcomes Program, Houston VA Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA.
J Clin Gastroenterol. 2012 Oct;46(9):779-88. doi: 10.1097/MCG.0b013e318266f6eb.
African Americans have lower reported likelihood of hepatitis C virus-related cirrhosis than whites. It is unknown whether relative differences in the distribution of adipose tissue, lean mass, and other anthropometric measurements may explain these observed interethnic differences in disease risk.
: To evaluate the association between anthropometric measurements and advanced liver disease in a cross-sectional study of African American and white male veterans.
We used the validated FibroSURE-ActiTest to assess hepatic pathology, and direct segmental multichannel bioelectric impedance analysis for anthropometric measurements. Race-stratified logistic regression was employed to evaluate risk of high fibrosis progression rate (FPR) and advanced inflammation (A2 to A3).
Among 330 eligible males (59% African American), there were 43 white and 57 African American males with high FPR, and 70 African American and 59 white with advanced inflammation. Percentage body fat (%BF) was a stronger predictor of high FPR risk than was a high body mass index in African Americans [odds ratio (OR)(adj)=2.08; 95% confidence interval (CI),0.83-5.23 for highest %BF vs. lowest tertile and OR(adj)=1.50; 95% CI,0.60-3.75 for obese vs. normal body mass index, respectively], but not in whites. Highest lean leg mass was associated with a nonsignificant increased risk of both high FPR and advanced inflammation in African Americans (OR(highFPRadj)=1.73; 95% CI, 0.73-4.10; OR(AdvancedinflammationAdj)=1.65; 95% CI, 0.76-3.56) versus a decreased risk of both in whites (OR(highFPRadj)=0.62; 95% CI, 0.21-1.79; OR(AdvancedinflammationAdj)=0.58; 95% CI, 0.22-1.48).
Interethnic differences in nontraditional anthropometric measurements like %BF suggests their potential role in understanding interethnic differences in hepatitis C virus-related liver disease risk in males.
非裔美国人报告的丙型肝炎病毒相关肝硬化的可能性低于白人。尚不清楚脂肪组织、瘦体重和其他人体测量学测量值的相对差异是否可以解释这些观察到的疾病风险的种族间差异。
在一项非裔美国人和白人男性退伍军人的横断面研究中，评估人体测量学测量值与晚期肝病的相关性。
我们使用经过验证的 FibroSURE-ActiTest 来评估肝病理，使用直接分段多通道生物电阻抗分析进行人体测量学测量。按种族分层的逻辑回归用于评估高纤维化进展率（FPR）和晚期炎症（A2 至 A3）的风险。
在 330 名符合条件的男性（59%为非裔美国人）中，有 43 名白人男性和 57 名非裔美国男性有高 FPR，70 名非裔美国男性和 59 名白人男性有晚期炎症。非裔美国人中体脂肪百分比（%BF）是高 FPR 风险的更强预测指标，而肥胖的体质指数则不然[比值比（OR）（调整）=2.08；95%置信区间（CI），最高%BF 与最低三分位相比为 0.83-5.23，而肥胖与正常体质指数相比为 1.50；95%CI，0.60-3.75]，但在白人中并非如此。最高的瘦腿质量与非裔美国人高 FPR 和晚期炎症的风险增加（OR（高 FPRadj）=1.73；95%CI，0.73-4.10；OR（高级炎症 Adj）=1.65；95%CI，0.76-3.56）而非白人中高 FPR 和晚期炎症的风险降低（OR（高 FPRadj）=0.62；95%CI，0.21-1.79；OR（高级炎症 Adj）=0.58；95%CI，0.22-1.48）有关。
非传统人体测量学测量值（如%BF）的种族间差异表明，它们可能在理解男性丙型肝炎病毒相关肝病风险的种族间差异方面发挥作用。
