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调制物对新皮层信息的门控作用。

The gating of neocortical information by modulators.

机构信息

The Picower Institute for Learning and Memory, Dept. of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

出版信息

J Neurophysiol. 2013 Mar;109(5):1229-32. doi: 10.1152/jn.00701.2012. Epub 2012 Sep 5.

DOI:10.1152/jn.00701.2012
PMID:22956786
Abstract

Thalamic input to the neocortex is crucial for sensory perception and constitutes the basis of complex awake behavior. Connections within the neocortex play an important role in internally generated neural activity, which is considered critical for memory retrieval and for the generation of imagery in our dreams. Modulatory neurotransmitters, such as noradrenaline and acetylcholine, gate information transmission in the brain. Favero et al. (J Neurophysiol 108: 1010-1024, 2012) show that modulators differentially facilitate thalamocortical relative to intracortical transmission in the input layers of cortex.

摘要

丘脑对新皮层的输入对于感觉感知至关重要,是复杂觉醒行为的基础。新皮层内的连接在内部产生的神经活动中起着重要作用,被认为对记忆检索和我们梦境中的意象产生至关重要。调制神经递质,如去甲肾上腺素和乙酰胆碱,调节大脑中的信息传递。Favero 等人(J Neurophysiol 108: 1010-1024, 2012)表明,在皮层输入层中,调制物有差异地促进了丘脑皮质相对于皮质内的传递。

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