Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Evid Based Complement Alternat Med. 2012;2012:731208. doi: 10.1155/2012/731208. Epub 2012 Aug 23.
Although cell transplantation strategies for spinal cord injury (SCI) using sources such as iPS cells and neural stem cells are focused as expectative therapies for SCI, the possibility of medication as more accessible and practical way should not be given up. We, therefore, aimed to develop medical sources for SCI. In this paper, we evaluated effects of a famous tonic herb, Epimedium koreanum, on motor dysfunction in spinal cord injury (SCI). The spinal cord was injured by contusion after laminectomy at T10 level. Oral administration of the methanol extract of E. koreanum significantly enhanced hindlimb function in SCI mice by short period treatment (for initial 3 days) and chronic treatment (21 days), although chronic treatment recovered the function more potently. Since it is well known that icariin is the major constituent in E. koreanum, icariin was administered orally to SCI mice for initial 3 days. Motor dysfunction was ameliorated by icariin treatment similarly to the methanol extract of E. koreanum. This paper is the first report to indicate E. koreanum is effective for recovery of motor function in SCI, and at least icariin is an active constituent.
虽然使用 iPS 细胞和神经干细胞等来源的细胞移植策略被视为脊髓损伤 (SCI) 的预期治疗方法，但不应放弃更易获得和实用的药物治疗可能性。因此，我们旨在开发用于 SCI 的医学来源。在本文中，我们评估了著名的滋补草药淫羊藿对脊髓损伤 (SCI) 运动功能障碍的影响。通过椎板切除术在 T10 水平损伤脊髓，然后用甲醇提取物进行口服给药。短期治疗（最初 3 天）和慢性治疗（21 天）均显著增强 SCI 小鼠的后肢功能，尽管慢性治疗的效果更强。由于众所周知淫羊藿苷是淫羊藿的主要成分，因此将淫羊藿苷口服给予 SCI 小鼠，治疗期为最初 3 天。运动功能障碍通过淫羊藿苷治疗得到改善，与淫羊藿的甲醇提取物相似。本文首次报道淫羊藿对 SCI 运动功能的恢复有效，至少淫羊藿苷是一种有效成分。
