Wang Zheng, Norton Loretta, Hutchison R Matthew, Ives John R, Mirsattari Seyed M
Department of Psychology, Vanderbilt University, Nashville, 37211 TN, USA.
Epilepsy Res Treat. 2012;2012:385626. doi: 10.1155/2012/385626. Epub 2012 Mar 8.
The combination of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has been shown to have great potential for providing a greater understanding of normal and diseased states in both human and animal studies. Simultaneous EEG-fMRI is particularly well suited for the study of epilepsy in that it may reveal the neurobiology of ictal and interictal epileptiform discharges and noninvasively localize epileptogenic foci. Spontaneous, coherent fluctuations of neuronal activity and the coupled hemodynamic responses have also been shown to provide diagnostic markers of disease, extending our understanding of intrinsically structured ongoing brain activity. Following a short summary of the hardware and software development of simultaneous EEG-fMRI, this paper reviews a unified framework of integrating neuronal and hemodynamic processes during epileptic seizures and discusses the role and impact of spontaneous activity in the mesial temporal lobe epilepsies with particular emphasis on the neural and physiological correlates of consciousness.
脑电图（EEG）与功能磁共振成像（fMRI）相结合，已被证明在人类和动物研究中，对于更深入理解正常和疾病状态具有巨大潜力。同步EEG-fMRI特别适合癫痫研究，因为它可能揭示发作期和发作间期癫痫样放电的神经生物学特征，并能无创定位致痫灶。神经元活动的自发、相干波动以及耦合的血液动力学反应也已被证明可提供疾病的诊断标志物，扩展了我们对内在结构化的持续脑活动的理解。在简要总结同步EEG-fMRI的硬件和软件开发之后，本文回顾了癫痫发作期间整合神经元和血液动力学过程的统一框架，并讨论了自发活动在颞叶内侧癫痫中的作用和影响，特别强调了意识的神经和生理相关性。
