Johns J A, Leavitt M B, Newell J B, Yasuda T, Leinbach R C, Gold H K, Finkelstein D, Dinsmore R E
Cardiac Unit, Massachusetts General Hospital, Boston 02114.
J Am Coll Cardiol. 1990 Jan;15(1):143-9. doi: 10.1016/0735-1097(90)90190-z.
Nuclear magnetic resonance (NMR) imaging has shown potential in the detection and characterization of acute myocardial infarction in humans. This study was performed to evaluate the capability of NMR imaging in the measurement of infarct size in patients with recent myocardial infarction. Electrocardiographic (ECG)-gated spin-echo NMR imaging was performed in 26 patients a mean of 9 +/- 3 days (range 5 to 20) after infarction. The imaging technique used provided single-slice, spin-echo (time to echo [TE] = 60 ms) images of the left ventricle in its true short axis, allowing direct correlation of NMR infarct location and size with the region of severe hypokinesia on left ventriculography. In all 20 patients with complete NMR studies, infarct location was correctly identified by using specific, objective criteria. The correlation between the mean infarct volume (29 +/- 11 ml) and the quantitated left ventricular hypokinetic segment (7.5 +/- 4.0 cm) was good (r = 0.84, p = 0.0002), suggesting that NMR imaging of the heart may have a role in the noninvasive assessment of myocardial infarct size in patients.
核磁共振（NMR）成像在检测和表征人类急性心肌梗死方面已显示出潜力。本研究旨在评估NMR成像在测量近期心肌梗死患者梗死面积方面的能力。对26例心肌梗死后平均9±3天（范围5至20天）的患者进行了心电图（ECG）门控自旋回波NMR成像。所采用的成像技术提供了左心室真正短轴的单层自旋回波（回波时间[TE]=60毫秒）图像，从而能够将NMR梗死部位和大小与左心室造影上严重运动减弱区域直接关联起来。在所有20例完成NMR研究的患者中，通过使用特定的客观标准正确识别了梗死部位。平均梗死体积（29±11毫升）与定量的左心室运动减弱节段（7.5±4.0厘米）之间的相关性良好（r = 0.84，p = 0.0002），这表明心脏的NMR成像可能在无创评估患者心肌梗死面积方面发挥作用。
