Department of Surgical and Perioperative Sciences, Surgery, Umeå University, SE-901 85, Umeå, Sweden.
Skin Res Technol. 2013 Feb;19(1):e473-8. doi: 10.1111/j.1600-0846.2012.00668.x. Epub 2012 Sep 7.
BACKGROUND/PURPOSE: An early diagnosis of cutaneous malignant melanoma is of high importance for good prognosis. An objective, non-invasive instrument could improve the diagnostic accuracy of melanoma and decrease unnecessary biopsies. The aim of this study was to investigate the use of Near-infrared and skin impedance spectroscopy in combination as a tool to distinguish between malignant and benign skin tumours.
Near-infrared and skin impedance spectra were collected in vivo on 50 naevi or suspect melanomas prior to excision. Received data were analysed using multivariate techniques and the results were compared to histopathology analyses of the tumours. A total of 12 cutaneous malignant melanomas, 19 dysplastic naevi and 19 benign naevi were included in the study.
The observed sensitivity and specificity of the proposed method were 83% and 95%, respectively, for malignant melanoma.
The results indicate that the combination of near-infrared and skin impedance spectroscopy is a promising tool for non-invasive diagnosis of suspect cutaneous malignant melanomas.
背景/目的：早期诊断皮肤恶性黑色素瘤对预后具有重要意义。客观、非侵入性的仪器可以提高黑色素瘤的诊断准确性，减少不必要的活检。本研究旨在探讨近红外和皮肤阻抗光谱联合作为一种工具来区分恶性和良性皮肤肿瘤。
在切除前，对 50 个痣或可疑黑素瘤进行体内近红外和皮肤阻抗光谱采集。使用多元技术分析接收数据，并将结果与肿瘤的组织病理学分析进行比较。共纳入 12 例皮肤恶性黑色素瘤、19 例发育不良痣和 19 例良性痣。
所提出方法的观察灵敏度和特异性分别为 83%和 95%，适用于恶性黑色素瘤。
结果表明，近红外和皮肤阻抗光谱联合是一种有前途的非侵入性诊断可疑皮肤恶性黑色素瘤的工具。
