在撒哈拉以南非洲地区，前瞻性评估 C 反应蛋白在新生儿败血症诊断中的作用。
Prospective evaluation of the usefulness of C-reactive protein in the diagnosis of neonatal sepsis in a sub-Saharan African region.
机构信息
Department of Paediatrics and Child Health, Niger Delta University Teaching Hospital, Okolobiri, Bayels State, Nigeria.
出版信息
Antimicrob Resist Infect Control. 2012 Jun 1;1(1):22. doi: 10.1186/2047-2994-1-22.
BACKGROUND
Sepsis is one of the most common causes of morbidity and mortality in the newborn. Early diagnosis and treatment is vital to improve outcome. The present study was therefore carried out to determine the usefulness of C-reactive protein (CRP) for evaluation of neonatal sepsis in Port Harcourt, Nigeria in Sub-Saharan Africa.
METHOD
Four hundred and twenty neonates with clinical suspicion of sepsis were prospectively studied over a 6 month period. Blood was obtained from each subject recruited for the qualitative estimation of CRP. Blood culture was used as gold standard for diagnosis of NNS.
RESULTS
Of 420 neonates studied, 196 (46.7%) had positive CRP while 181 (43.1%) had positive blood culture. The sensitivity, specificity, positive and negative predictive values of CRP were 74.0%, 74.1%, 68.4% and 79.0% respectively.
CONCLUSION
The qualitative method of estimating CRP which is cheap and rapid has moderate sensitivity, specificity and negative predictive value.
背景
败血症是新生儿发病率和死亡率的最常见原因之一。早期诊断和治疗对改善预后至关重要。因此，本研究旨在确定 C 反应蛋白（CRP）在尼日利亚哈科特港（撒哈拉以南非洲）评估新生儿败血症的有用性。
方法
在 6 个月的时间内，前瞻性研究了 420 名有败血症临床疑似症状的新生儿。从每位纳入研究的受试者中抽取血液，定性估计 CRP。血液培养被用作诊断新生儿败血症的金标准。
结果
在研究的 420 名新生儿中，196 名（46.7%）CRP 阳性，181 名（43.1%）血培养阳性。CRP 的灵敏度、特异性、阳性预测值和阴性预测值分别为 74.0%、74.1%、68.4%和 79.0%。
结论
这种定性估计 CRP 的方法既便宜又快速，具有中等的灵敏度、特异性和阴性预测值。
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