Department of Microbiology and Immunology, 1300 York Avenue, New York, NY, 10065, USA.
Cell Biosci. 2012 Sep 10;2(1):31. doi: 10.1186/2045-3701-2-31.
Golgi phosphoprotein 2 (GOLPH2, also termed GP73 and GOLM1) is a type II transmembrane protein residing in the cis and medial-Golgi cisternae. GOLPH2 is predominantly expressed in the epithelial cells of many human tissues. Under poorly defined circumstances, GOLPH2 can be cleaved and released to the extracellular space. Despite of its relatively "young age" since the first description in 2000, the physiological and pathological roles of GOLPH2 have been the subject that has attracted considerable amount of attention in recent years. Here, we review the history of GOLPH2's discovery and the multitude of studies by many groups around the world aimed at understanding its molecular, cellular, physiological, and pathogenic activities in various settings.
高尔基体磷蛋白 2（GOLPH2，也称为 GP73 和 GOLM1）是一种 II 型跨膜蛋白，位于顺面和中间高尔基体潴泡腔内。GOLPH2 主要表达于多种人体组织的上皮细胞中。在定义不明确的情况下，GOLPH2 可被切割并释放到细胞外空间。尽管自 2000 年首次描述以来它相对“年轻”，但近年来，GOLPH2 的生理和病理作用一直是吸引众多研究小组关注的主题。在这里，我们回顾了 GOLPH2 的发现历史以及世界各地许多研究小组的众多研究，旨在了解其在各种环境中的分子、细胞、生理和致病活性。
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