Litscher G, Friehs G, Maresch H, Pfurtscheller G
Department of Medical Informatics, Technical University of Graz, Austria.
J Clin Monit. 1990 Jan;6(1):10-7. doi: 10.1007/BF02832177.
The purpose of this study was to investigate brain bioelectrical activity during hyperbaric oxygenation by continuous and simultaneous monitoring of electroencephalographic and bimodal (auditory, somatosensory) evoked potentials. Multivariable recordings (electroencephalogram, brainstem auditory evoked potentials, early somatosensory evoked potentials, heart rate, heart rate variability, and transcutaneous partial pressure of oxygen) were measured with a new technique in 12 healthy male volunteers 26 to 52 years old (mean +/- SD, 35.9 +/- 9.5 years). Recordings were obtained while the subjects breathed (1) air at normal atmospheric pressure, (2) 100% oxygen at normal atmospheric pressure, (3) air at 2 atm (10 meters sea water [msw]), and (4) 100% oxygen at 2 atm (10 msw). Spontaneous brain electrical activity, somatosensory evoked potentials, and heart rate variability were not significantly affected during hyperbaric oxygenation, whereas the heart rate showed a significant decrease (paired t test, P less than 0.05). Alterations in brainstem auditory evoked potentials were seen under hyperbaric conditions and did not reach statistical significance (increase of the I-V interpeak latency by paired t test; P less than 0.2). All subjects showed insignificant increases in dominant alpha frequency and decreases in delta frequency under hyperbaric situations.
本研究的目的是通过连续同步监测脑电图和双模式（听觉、躯体感觉）诱发电位来探究高压氧疗期间的脑生物电活动。采用一项新技术对12名年龄在26至52岁（平均±标准差，35.9±9.5岁）的健康男性志愿者进行多变量记录（脑电图、脑干听觉诱发电位、早期躯体感觉诱发电位、心率、心率变异性和经皮氧分压）。在受试者呼吸以下气体时进行记录：(1)常压空气；(2)常压100%氧气；(3)2个大气压（10米海水深度[msw]）的空气；(4)2个大气压（10 msw）的100%氧气。高压氧疗期间，自发脑电活动、躯体感觉诱发电位和心率变异性未受到显著影响，而心率显著下降（配对t检验，P<0.05）。在高压条件下观察到脑干听觉诱发电位有改变，但未达到统计学意义（配对t检验I-V峰间期潜伏期增加；P<0.2）。所有受试者在高压情况下优势α频率均有不显著增加，δ频率均有下降。
