Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
Int J Infect Dis. 2012 Dec;16(12):e855-9. doi: 10.1016/j.ijid.2012.07.013. Epub 2012 Sep 7.
This study evaluated inducible protein 10 (IP-10) as a diagnostic biomarker for specific tuberculosis (TB) infection and evaluated the ability of IP-10 to distinguish between active TB and latent TB infection (LTBI).
Forty-six patients with active pulmonary TB, 22 participants with LTBI, and 32 non-TB controls were enrolled separately. We measured IP-10 in serum and in supernatants from whole blood stimulated with TB-specific antigens.
TB antigen-dependent IP-10 secretion was significantly increased in the active TB patients and LTBI subjects compared with controls, but did not differ significantly between the active TB patients and LTBI subjects. Serum IP-10 levels were higher in active TB than in LTBI (174.9 vs. 102.7pg/ml, p=0.002). The respective rates of positive responders of TB antigen-dependent IP-10 were 97.8%, 90.9%, and 12.5% in active TB, LTBI, and non-TB controls, respectively. For serum IP-10, 87.5%, 45.5%, and 9.5% of responders were positive in the respective groups.
The IP-10 response to TB antigen may constitute a specific biomarker for TB infection, but does not by itself distinguish between active TB and LTBI. Serum IP-10 may enhance the diagnostic performance when used in combination with another marker.
本研究评估诱导蛋白 10（IP-10）作为特定结核病（TB）感染的诊断生物标志物，并评估 IP-10 区分活动性 TB 和潜伏性 TB 感染（LTBI）的能力。
分别纳入 46 例活动性肺结核患者、22 例 LTBI 参与者和 32 例非 TB 对照者。我们测量了血清和 TB 特异性抗原刺激全血上清液中的 IP-10。
与对照组相比，TB 抗原依赖性 IP-10 分泌在活动性 TB 患者和 LTBI 受试者中显著增加，但在活动性 TB 患者和 LTBI 受试者之间无显著差异。与 LTBI 相比，血清 IP-10 水平在活动性 TB 中更高（174.9 比 102.7pg/ml，p=0.002）。TB 抗原依赖性 IP-10 的阳性反应率分别为活动性 TB 97.8%、LTBI 90.9%和非 TB 对照组 12.5%。对于血清 IP-10，相应组中 87.5%、45.5%和 9.5%的反应者为阳性。
TB 抗原的 IP-10 反应可能构成 TB 感染的特异性生物标志物，但不能单独区分活动性 TB 和 LTBI。当与另一种标志物联合使用时，血清 IP-10 可能会提高诊断性能。
