Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Ann Thorac Surg. 2012 Nov;94(5):1688-94. doi: 10.1016/j.athoracsur.2012.07.034. Epub 2012 Sep 7.
Previous thoracic artificial lungs (TALs) had blood flow impedance greater than that of the natural lungs, which could cause abnormal pulmonary hemodynamics. New compliant TALs (cTALs), however, have an impedance lower than that of the natural lung.
In this study, a cTAL of new design was attached between the pulmonary artery (PA) and the left atrium (LA) in 5 sheep (60.2 ± 1.9 kg). A distal PA band was placed to control the percentage of cardiac output (CO) routed to the cTAL. Rest and exercise conditions were simulated using a continuous dobutamine infusion of 0 and 5 μg/kg/min, respectively. At each dose, a hemodynamic data set was acquired at baseline (no flow to the cTAL), and 60%, 75%, and 90% of CO was shunted to the cTAL.
Device resistance did not vary with blood flow rate, averaging 0.51 ± 0.03 mm Hg/(L/min). Under all conditions, CO was not significantly different from baseline. Pulmonary system impedance increased above baseline only with 5 μg/kg/min of dobutamine and 90% of CO diverted to the cTAL.
Results indicated minimal changes in pulmonary hemodynamics during PA-LA cTAL attachment for high device flows under rest and exercise conditions.
以前的胸腔人工肺（TAL）的血流阻抗大于自然肺，这可能导致肺血流动力学异常。然而，新型顺应性 TAL（cTAL）的阻抗低于自然肺。
在这项研究中，将新型 cTAL 连接在肺动脉（PA）和左心房（LA）之间，实验羊 5 只（60.2±1.9kg）。放置远端 PA 带以控制流向 cTAL 的心输出量（CO）的百分比。使用 0 和 5μg/kg/min 的持续多巴酚丁胺输注分别模拟休息和运动条件。在每个剂量下，在基线（无血流流向 cTAL）和 60%、75%和 90%的 CO 分流至 cTAL 时，获得一组血流动力学数据。
装置阻力与血流量无关，平均为 0.51±0.03mm Hg/（L/min）。在所有条件下，CO 与基线相比无显著差异。只有在多巴酚丁胺 5μg/kg/min 和 90%的 CO 分流至 cTAL 时，肺系统阻抗才高于基线。
结果表明，在休息和运动条件下，高设备流量下 PA-LA cTAL 连接时，肺血流动力学变化极小。
