胃癌患者血浆 kisspeptin-54 水平。

Plasma Kisspeptin-54 levels in gastric cancer patients.

机构信息

Istanbul University, Institute of Experimental Medicine Research, Department of Molecular Medicine, and American Hospital, General Surgery Clinic, Istanbul 34100, Turkey.

出版信息

Int J Surg. 2012;10(9):551-4. doi: 10.1016/j.ijsu.2012.08.014. Epub 2012 Sep 5.

DOI:10.1016/j.ijsu.2012.08.014

PMID:22959969

Abstract

BACKGROUND

Kisspeptin (Kisspeptin-54; KP-54) is a 54-amino acid peptide was originally known as metastin that was implicated in suppression of tumor metastasis and circulating kisspeptin has been proposed as a tumor marker for numerous cancers in humans. However, the plasma level of KP-54 in gastric cancer (GC) remains undetermined.

AIM

We aimed to investigate the plasma levels of KP-54 in patients with GC.

METHODS

Plasma KP-54 levels were quantified with enzyme-immunoassay from blood samples of 40 patients with GC at their initial staging and 59 age-matched controls.

RESULTS

Plasma KP-54 levels were significantly higher in GC patients (63.3±17.9) than in controls (49.0±12.7) (p=0.000). Cut-off value for KP-54 was determined as 44 ng/ml and sensitivity, specificity, positive predictive value and negative predictive value, were 60%, 78%, 63%, and 74% respectively. Plasma KP-54 levels were not correlated with any clinicopathological features of GC patients (p>0.05).

CONCLUSIONS

Result of our preliminary study suggest that plasma KP-54 levels might be a useful parameter in diagnosis of GC.

摘要

背景

Kisspeptin（Kisspeptin-54；KP-54）是一种 54 个氨基酸的肽，最初被称为 Metastatin，它被认为可以抑制肿瘤转移，并且已经有人提出循环 Kisspeptin 可作为人类多种癌症的肿瘤标志物。然而，胃癌（GC）患者的 KP-54 血浆水平仍未确定。

目的

我们旨在研究 GC 患者的 KP-54 血浆水平。

方法

采用酶联免疫吸附法从 40 例初诊 GC 患者和 59 名年龄匹配的对照者的血样中定量测定 KP-54 水平。

结果

GC 患者的 KP-54 血浆水平（63.3±17.9）显著高于对照组（49.0±12.7）（p=0.000）。KP-54 的截断值为 44ng/ml，灵敏度、特异性、阳性预测值和阴性预测值分别为 60%、78%、63%和 74%。KP-54 血浆水平与 GC 患者的任何临床病理特征均无相关性（p>0.05）。