Institute of Nuclear Medicine, Catholic University of Sacred Heart, Rome, Italy.
J Crohns Colitis. 2013 Jun;7(5):345-54. doi: 10.1016/j.crohns.2012.08.005. Epub 2012 Sep 7.
To systematically review and meta-analyze published data about the diagnostic performance of Fluorine-18-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) in patients with chronic inflammatory bowel disease (IBD).
A comprehensive computer literature search of studies published through May 2012 regarding (18)F-FDG-PET and PET/CT in patients with IBD was performed. All retrieved studies were reviewed and qualitatively analyzed. Pooled sensitivity, specificity, positive and negative likelihood ratio (LR+ and LR-) and diagnostic odd ratio (DOR) of (18)F-FDG PET and PET/CT in patients with IBD on a per segment-based analysis were calculated. The area under the ROC curve was calculated to measure the accuracy of (18)F-FDG PET and PET/CT in patients with IBD.
Nineteen studies comprising 454 patients with suspected IBD were included in the qualitative analysis (systematic review) and discussed. The quantitative analysis (meta-analysis) of seven selected studies (including 219 patients with IBD) provided the following results on a per segment-based analysis: sensitivity was 85% [95% confidence interval (95%CI) 81-88%], specificity 87% (95%CI 84-90%), LR+ 6.19 (95%CI: 2.86-13.41), LR- 0.19 (95%CI: 0.10-0.34), and DOR 44.35 (95%CI: 11.77-167.07). The area under the ROC curve was 0.933.
In patients with suspected IBD (18)F-FDG PET and PET/CT demonstrated good sensitivity and specificity, being accurate methods in this setting. Nevertheless, the literature focusing on the use of PET and PET/CT in IBD remains still limited; thus, further large multicenter studies will be necessary to substantiate the diagnostic accuracy of these methods in patients with IBD.
系统回顾和荟萃分析已发表的关于氟-18-氟代脱氧葡萄糖（18 F-FDG）正电子发射断层扫描（PET）和 PET/计算机断层扫描（PET/CT）在慢性炎症性肠病（IBD）患者中的诊断性能的文献。
通过 2012 年 5 月前对 IBD 患者 18 F-FDG-PET 和 PET/CT 的综合计算机文献检索进行研究。对所有检索到的研究进行了回顾和定性分析。计算了 IBD 患者基于每节段的 18 F-FDG PET 和 PET/CT 的合并敏感性、特异性、阳性和阴性似然比（LR+和 LR-）以及诊断比值比（DOR）。计算了受试者工作特征曲线下的面积以衡量 18 F-FDG PET 和 PET/CT 在 IBD 患者中的准确性。
在定性分析（系统综述）和讨论中纳入了 19 项包含 454 例疑似 IBD 患者的研究。对 7 项选定研究（包括 219 例 IBD 患者）的定量分析（荟萃分析）提供了以下基于每节段的分析结果：敏感性为 85%[95%置信区间（95%CI）81-88%]，特异性为 87%（95%CI 84-90%），LR+为 6.19（95%CI：2.86-13.41），LR-为 0.19（95%CI：0.10-0.34），DOR 为 44.35（95%CI：11.77-167.07）。ROC 曲线下的面积为 0.933。
在疑似 IBD 患者中，18 F-FDG PET 和 PET/CT 显示出良好的敏感性和特异性，是该情况下准确的方法。然而，关于 PET 和 PET/CT 在 IBD 中的应用的文献仍然有限；因此，需要进一步的大型多中心研究来证实这些方法在 IBD 患者中的诊断准确性。
