Abikhzer Gad, Treglia Giorgio, Pelletier-Galarneau Matthieu, Buscombe John, Chiti Arturo, Dibble Elizabeth H, Glaudemans Andor W J M, Palestro Christopher J, Sathekge Mike, Signore Alberto, Jamar Francois, Israel Ora, Gheysens Olivier
Department of Medical Imaging, Faculty of Medicine and Health Sciences, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Eur J Nucl Med Mol Imaging. 2025 Jan;52(2):510-538. doi: 10.1007/s00259-024-06915-3. Epub 2024 Oct 10.
Hybrid [F]FDG PET imaging is currently the method of choice for a wide variety of infectious and inflammatory disorders and was recently adopted in several clinical guidelines. A large amount of evidence-based articles, guidelines and appropriate use criteria have been published since the first version of this guideline in 2013.
To provide updated evidence-based information to assist physicians in recommending, performing and interpreting hybrid [F]FDG PET examinations for infectious and inflammatory disorders in the adult population.
A systematic literature search of evidence-based articles using whole-body [F]FDG hybrid imaging on the indications covered within this guideline was performed. All systematic reviews and meta-analyses published within the last 10 years until January 2023 were identified in PubMed/Medline or Cochrane. For each indication covered in this manuscript, diagnostic performance was provided based on meta-analyses or systematic reviews. If not available, results from prospective or retrospective studies were considered based on predefined selection criteria. RESULTS AND CONCLUSIONS: Hybrid [F]FDG PET is extremely useful in the work-up and management of adults with infectious and inflammatory diseases, as supported by extensive and rapidly growing evidence-based literature and adoption in clinical guidelines. Practical recommendations are provided describing evidence-based indications as well as interpretation criteria and pitfalls. Monitoring treatment response is the most challenging but insufficiently studied potential application in infection and inflammation imaging.
[F]FDG 混合 PET 成像目前是多种感染性和炎症性疾病的首选检查方法，最近已被纳入多项临床指南。自本指南 2013 年第一版发布以来，已经发表了大量基于证据的文章、指南和合理使用标准。
提供最新的循证信息，以帮助医生推荐、进行和解读针对成人感染性和炎症性疾病的[F]FDG 混合 PET 检查。
对本指南涵盖的适应症，使用全身[F]FDG 混合成像进行基于证据的文章的系统文献检索。在 PubMed/Medline 或 Cochrane 中检索了截至 2023 年 1 月的过去 10 年内发表的所有系统评价和荟萃分析。对于本手稿涵盖的每个适应症，基于荟萃分析或系统评价提供诊断性能。如果没有，则根据预定义的选择标准考虑前瞻性或回顾性研究的结果。结果与结论：广泛且快速增长的循证文献以及临床指南中的采用情况均支持，[F]FDG 混合 PET 在成人感染性和炎症性疾病的检查和管理中极为有用。提供了实用建议，描述了基于证据的适应症以及解读标准和陷阱。监测治疗反应是感染和炎症成像中最具挑战性但研究不足的潜在应用。
