DeNobile J, Guzzetta P, Patterson K
Department of Surgery, Children's Hospital National Medical Center, Washington, D.C.
J Surg Res. 1990 Jan;48(1):21-3. doi: 10.1016/0022-4804(90)90139-s.
Utilizing a pulse oximeter, oxygen saturation was determined in the periphery (tongue) and compared to the intestinal wall in a canine model. Segmental intestinal ischemia was then produced and the last obtainable pulse oximetry reading was marked with a suture on either end of the ischemic segment. Reexploration was performed within 48 hr and full thickness biopsies were taken in normal intestine and at various distances into the ischemic segment. Blinded evaluation of the biopsies showed that all biopsies taken within 1 cm of a normal pulse oximetry reading were normal, whereas at 3 cm into the ischemic segment 7 of 15 biopsies showed partial necrosis and 5 of 15 showed full thickness necrosis. We conclude that pulse oximetry of the intestinal wall is a valuable method of assessing intestinal viability in this model.
在犬类模型中，使用脉搏血氧仪测定外周（舌头）的氧饱和度，并与肠壁的氧饱和度进行比较。然后造成节段性肠缺血，在缺血段两端用缝线标记最后可获得的脉搏血氧饱和度读数。在48小时内进行再次探查，并在正常肠段和缺血段不同距离处取全层活检组织。对活检组织进行盲法评估显示，在脉搏血氧饱和度读数正常的1厘米范围内所取的所有活检组织均正常，而在缺血段3厘米处，15份活检组织中有7份显示部分坏死，15份中有5份显示全层坏死。我们得出结论，在该模型中，肠壁脉搏血氧饱和度测定是评估肠活力的一种有价值的方法。
