Povlsen U J, Pakkenberg H
Department of Neurology, Hvidovre University Hospital, Copenhagen, Denmark.
Mov Disord. 1990;5(1):27-31. doi: 10.1002/mds.870050107.
The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6). Eleven patients had primary dystonia, and 3 patients had a secondary form of dystonia. Doses of 5 mg of biperiden reduced dystonia when evaluated by total scores, global scores, and subjective scores. Two patients had marked side effects in the form of dizziness. Doses of 1 mg of clonazepam significantly reduced total scores and subjective scores, but the reduction in global score was insignificant. No patient had marked side effects following injection with clonazepam. These results correspond with earlier investigations of the long-term effects of anticholinergics and benzodiazepines. It is concluded that in some cases, intravenous injections can be used as a test for evaluating both effects and side effects of antidystonic medication prior to the institution of oral treatment. Long-term intravenous treatment might be considered in individual cases.
对14例患有各种形式肌张力障碍的患者（节段性肌张力障碍2例、全身性肌张力障碍6例、Meige综合征6例）进行了静脉注射比哌立登和氯硝西泮的急性效应研究。11例患者为原发性肌张力障碍，3例患者为继发性肌张力障碍。以总分、整体评分和主观评分评估时，5mg比哌立登剂量可减轻肌张力障碍。2例患者出现以头晕形式表现的明显副作用。1mg氯硝西泮剂量可显著降低总分和主观评分，但整体评分的降低不显著。注射氯硝西泮后无患者出现明显副作用。这些结果与早期抗胆碱能药物和苯二氮䓬类药物长期效应的研究结果相符。得出的结论是，在某些情况下，静脉注射可作为在开始口服治疗前评估抗肌张力障碍药物的疗效和副作用的一种试验。个别病例可考虑长期静脉治疗。
