Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, 48109-0656, USA.
Curr Med Chem. 2012;19(35):6050-5.
Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the most lethal cancers. There is increasing evidence that cancer stem cells within GBMs, which are often referred to as glioblastoma stem cells (GSCs), play a critical role in tumor initiation and maintenance. Identification of novel markers for GSCs will lead to better targeting of GSCs which could have tremendous impact on treatment of GBMs. Cell surface markers are particularly suitable as therapeutic targets. Although several promising cell surface markers have successfully been used for enrichment of GSCs, their functional roles in maintenance of GSC properties as well as in GBM formation and development remain to be characterized. In this review, we primarily summarize recent advances in identification of GSC markers, with a particular focus on cell surface markers.
多形性胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤，也是最致命的癌症之一。越来越多的证据表明，GBM 中的癌症干细胞，通常被称为胶质母细胞瘤干细胞（GSCs），在肿瘤的发生和维持中起着关键作用。鉴定 GSCs 的新型标志物将有助于更有效地靶向 GSCs，这可能对 GBM 的治疗产生巨大影响。细胞表面标志物特别适合作为治疗靶点。虽然已经有几种有前途的细胞表面标志物成功地用于富集 GSCs，但它们在维持 GSC 特性以及在 GBM 形成和发展中的功能作用仍有待阐明。在这篇综述中，我们主要总结了鉴定 GSC 标志物的最新进展，特别关注细胞表面标志物。
