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丁卡因溶液用于经口硬质喉镜检查局部麻醉的交叉研究。

Cross-over study of topical anaesthesia with tetracaine solution for transoral rigid laryngoscopy.

作者信息

Zhu Z-H, Zheng J, Ying L-Y, Zhu B-W, Qian J, Ma Z-X

机构信息

Department of Otolaryngology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

J Laryngol Otol. 2012 Nov;126(11):1150-4. doi: 10.1017/S002221511200182X. Epub 2012 Sep 11.

Abstract

BACKGROUND

Transoral rigid laryngoscopy with videostroboscopy is the most practical method to visualise the vocal folds. The optimal topical anaesthesia regimen for transoral rigid laryngoscopy has not yet been established.

OBJECTIVE

To compare patient comfort and compliance with various topical anaesthetics for transoral rigid laryngoscopy.

METHODS

Each of 10 patients received a random topical administration of either 2 per cent lidocaine gel, 1 per cent tetracaine gel or 1 per cent tetracaine solution, 10 minutes before undergoing rigid laryngoscopy with videostroboscopy. During follow-up laryngoscopies, the agent with the lowest mean visual analogue scale score for discomfort was then used to study the timing of topical anaesthetic application: the agent was given to the patient 5, 10 or 15 minutes before laryngoscopy (with the timing randomly selected).

RESULTS

Compared with lidocaine gel or tetracaine gel, laryngoscopy with topical tetracaine solution was more comfortable. There was a statistically significant difference in discomfort score between the 5 and 10 minute application groups, but not between the 10 and 15 minute groups.

CONCLUSION

Tetracaine solution, applied topically 10 minutes before transoral rigid laryngoscopy, significantly decreases patient discomfort.

摘要

背景

经口硬质喉镜联合频闪喉镜检查是观察声带的最实用方法。经口硬质喉镜检查的最佳局部麻醉方案尚未确定。

目的

比较经口硬质喉镜检查中不同局部麻醉剂的患者舒适度和依从性。

方法

10例患者在接受硬质喉镜联合频闪喉镜检查前10分钟,随机接受2%利多卡因凝胶、1%丁卡因凝胶或1%丁卡因溶液的局部给药。在后续喉镜检查中,使用平均视觉模拟评分法中不适评分最低的药物来研究局部麻醉剂的应用时间:在喉镜检查前5、10或15分钟给患者使用该药物(时间随机选择)。

结果

与利多卡因凝胶或丁卡因凝胶相比,使用局部丁卡因溶液进行喉镜检查更舒适。5分钟和10分钟给药组之间的不适评分有统计学显著差异,但10分钟和15分钟给药组之间没有。

结论

经口硬质喉镜检查前10分钟局部应用丁卡因溶液可显著减轻患者不适。

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