Suppr超能文献

[肺泡出血]

[Alveolar hemorrhage].

作者信息

Traclet J, Lazor R, Cordier J-F, Cottin V

机构信息

INRA, UMR754 INRA-Vetagrosup EPHE IFR 128, université de Lyon, université Claude-Bernard Lyon 1, Lyon, France.

出版信息

Rev Med Interne. 2013 Apr;34(4):214-23. doi: 10.1016/j.revmed.2012.08.002. Epub 2012 Sep 7.

Abstract

Diffuse alveolar hemorrhage (DAH) is defined by the presence of red blood cells originating from the lung capillaries or venules within the alveoli. The diagnosis is established on clinical features, radiological pattern, and especially bronchoalveolar lavage. Diffuse alveolar hemorrhage may have many immune or non-immune causes. Immune causes of DAH include vasculitides, connective tissue diseases, especially systemic lupus erythematosus, and antiglomerular basement membrane antibody disease (Goodpasture's syndrome). Treatment is both supportive and causal, often based on high dose corticosteroids and immunosuppressive therapy (especially intravenous cyclophosphamide). Plasma exchanges are performed in antiglomerular basement membrane antibody disease and systemic lupus erythematosus, and are considered in systemic vasculitis. Non-immune causes of DAH mainly include heart diseases, coagulation disorders, infections, drug toxicities and idiopathic DAH. Treatment of non-immune DAH is that of its cause. Whatever the cause, DAH is an emergency requiring prompt assessment and early treatment.

摘要

弥漫性肺泡出血(DAH)的定义是肺泡内存在源自肺毛细血管或小静脉的红细胞。诊断基于临床特征、影像学表现,尤其是支气管肺泡灌洗。弥漫性肺泡出血可能有多种免疫或非免疫原因。DAH的免疫原因包括血管炎、结缔组织病,尤其是系统性红斑狼疮,以及抗肾小球基底膜抗体病(Goodpasture综合征)。治疗包括支持治疗和针对病因的治疗,通常基于大剂量皮质类固醇和免疫抑制疗法(尤其是静脉注射环磷酰胺)。在抗肾小球基底膜抗体病和系统性红斑狼疮中进行血浆置换,在系统性血管炎中也可考虑进行。DAH的非免疫原因主要包括心脏病、凝血障碍、感染、药物毒性和特发性DAH。非免疫性DAH的治疗是针对其病因。无论病因如何,DAH都是一种紧急情况,需要及时评估和早期治疗。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验