miRNA 调控非编码 RNA：一种非经典功能模型。
miRNA regulates noncoding RNA: a noncanonical function model.
机构信息
Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China.
出版信息
Trends Biochem Sci. 2012 Nov;37(11):457-9. doi: 10.1016/j.tibs.2012.08.005. Epub 2012 Sep 8.
It has long been assumed that miRNAs can only target protein-coding mRNAs in the cytoplasm. Recent studies, however, reveal miRNAs are also transported from the cytoplasm to the nucleus, where they function in a noncanonical manner to regulate noncoding RNAs. Here, we highlight the working model of these noncanonical miRNAs.
长期以来，人们一直认为 miRNA 只能靶向细胞质中的蛋白质编码 mRNA。然而，最近的研究表明，miRNA 也可以从细胞质运输到细胞核，在细胞核中以非典型方式发挥作用，调节非编码 RNA。在这里，我们重点介绍这些非典型 miRNA 的工作模式。
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