Department of Microbiology & Immunology, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada.
Curr Opin Virol. 2012 Oct;2(5):644-50. doi: 10.1016/j.coviro.2012.08.004. Epub 2012 Sep 8.
The selection of resistance to antiviral drugs depends on multiple parameters, including the genetic barrier that is often broadly defined as the number of mutations required to overcome drug selective pressure. In this review, it is intended to assess the roles of genetic barrier and viral fitness at various stages of the selection process. Several examples in the fields of HIV and HCV drug resistance show that the two parameters are distinct and independent. An analogy to the concept of kinetic versus thermodynamic control of chemical reactions supports a more narrow definition of the genetic barrier as the kinetic obstacle for the generation of genetic changes required to overcome selective pressure.
抗病毒药物耐药性的选择取决于多个参数，包括遗传屏障，通常广义地定义为克服药物选择压力所需的突变数量。在这篇综述中，旨在评估遗传屏障和病毒适应性在选择过程的各个阶段的作用。HIV 和 HCV 耐药性领域的几个例子表明，这两个参数是不同的和独立的。将化学反应的动力学控制与热力学控制的概念进行类比，可以将遗传屏障的定义更狭义地定义为克服选择压力所需的遗传变化产生的动力学障碍。
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