Martinez A M, Padbury J F, Burnell E E, Thio S L, Humme J
Harbor-UCLA Medical Center, Torrance 90509.
Pediatr Res. 1990 Jan;27(1):52-5. doi: 10.1203/00006450-199001000-00016.
The effect of hypoxia on plasma met-enkephalin and catecholamine levels was studied in chronically catheterized fetal sheep. Maternal and fetal hypoxia was maintained for 20 min. We found hypoxia significantly increased the plasma levels of large mol wt met-enkephalin containing peptides from 1755 +/- 229 pg/mL during baseline to 4408 +/- 1426 pg/mL by 15 minutes of hypoxia. The levels of the met-enkephalin pentapeptide were unchanged during hypoxia from a baseline value of 168 +/- 56 pg/mL. Norepinephrine and epinephrine levels increased 5- and 10-fold, respectively, by 15 min of hypoxia. These observations suggest cosecretion of the large mol wt met-enkephalin peptides with catecholamines during stress in developing animals.
在长期插管的胎羊中研究了缺氧对血浆中甲硫氨酸脑啡肽和儿茶酚胺水平的影响。维持母体和胎儿缺氧20分钟。我们发现，缺氧显著增加了含大分子质量甲硫氨酸脑啡肽肽段的血浆水平，从基线时的1755±229 pg/mL在缺氧15分钟时升高至4408±1426 pg/mL。甲硫氨酸脑啡肽五肽的水平在缺氧期间从基线值168±56 pg/mL未发生变化。缺氧15分钟时，去甲肾上腺素和肾上腺素水平分别增加了5倍和10倍。这些观察结果表明，在发育中的动物应激期间，大分子质量甲硫氨酸脑啡肽肽段与儿茶酚胺共同分泌。
