Grupo de Espectroscopía Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Parque Científico UVa, Universidad de Valladolid, 47005 Valladolid, Spain.
Phys Chem Chem Phys. 2012 Oct 21;14(39):13618-23. doi: 10.1039/c2cp42654d.
A laser ablation device in combination with a molecular beam Fourier-transform microwave spectrometer has allowed the observation of the rotational spectrum of serotonin for the first time. Three conformers of the neurotransmitter have been detected and characterized in the 4-10 GHz frequency range. The complicated hyperfine structure arising from the presence of two (14)N nuclei has been fully resolved for all conformers and used for their identification. Nuclear quadrupole coupling constants of the nitrogen atom of the side chain have been used to determine the orientation of the amino group probing the existence of N-Hπ interactions involving the amino group and the pyrrole unit in the Gauche-Phenyl conformer (GPh) or the phenyl unit in the Gauche-Pyrrole (GPy) ones.
一种激光烧蚀装置与分子束傅里叶变换微波光谱仪相结合，首次允许观察到血清素的旋转光谱。在 4-10GHz 的频率范围内，已经检测到并表征了神经递质的三种构象。由于存在两个(14)N 核，出现了复杂的超精细结构，所有构象均已完全解析，并用于它们的识别。侧链氮原子的核四极耦合常数用于确定氨基的取向，探测涉及氨基和吡咯单元的 Gauche-Phenyl（GPh）构象或苯单元的 Gauche-Pyrrole（GPy）构象中的 N-Hπ 相互作用的存在。
