Brodsky Michael C
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Arch Ophthalmol. 2012 Sep;130(9):1199-202. doi: 10.1001/archophthalmol.2012.2067.
A recent editorial in the Archives assigned the primary pathogenesis of infantile esotropia to the visual cortex. This analysis addresses the limitations of this timeworn view and advances the perspective that infantile esotropia is a cortico-mesencephalic-cerebellar disorder wherein binocular cortical maldevelopment permits atavistic subcortical visual pathways to remain operational. This integrated neuroanatomical model predicts that primary neurodevelopmental disorders involving the accessory optic system or its connections to the cerebellum can also give rise to infantile esotropia.
《Archives》最近的一篇社论将婴儿内斜视的主要发病机制归因于视觉皮层。本分析阐述了这一陈旧观点的局限性，并提出婴儿内斜视是一种皮质-中脑-小脑疾病的观点，即双眼皮质发育异常使返祖性皮质下视觉通路仍可运作。这种整合的神经解剖学模型预测，涉及附属视觉系统或其与小脑连接的原发性神经发育障碍也可导致婴儿内斜视。
