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Sevoflurane exposure in 7-day-old rats affects neurogenesis, neurodegeneration and neurocognitive function.
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From the Cover: Volatile Anesthetics Transiently Disrupt Neuronal Development in Neonatal Rats.
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Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction.
Anaesthesist. 2017 Nov;66(11):850-857. doi: 10.1007/s00101-017-0359-4. Epub 2017 Sep 15.
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Neonatal Repeated Exposure to Isoflurane not Sevoflurane in Mice Reversibly Impaired Spatial Cognition at Juvenile-Age.
Neurochem Res. 2017 Feb;42(2):595-605. doi: 10.1007/s11064-016-2114-7. Epub 2016 Nov 24.
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Sevoflurane causes neuronal apoptosis and adaptability changes of neonatal rats.
Acta Anaesthesiol Scand. 2013 Oct;57(9):1167-74. doi: 10.1111/aas.12163. Epub 2013 Jul 29.
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Erythropoietin protects newborn rat against sevoflurane-induced neurotoxicity.
Paediatr Anaesth. 2014 Jul;24(7):749-59. doi: 10.1111/pan.12372. Epub 2014 Apr 12.

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Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles.
Front Cell Dev Biol. 2025 Jun 30;13:1613378. doi: 10.3389/fcell.2025.1613378. eCollection 2025.
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Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models.
Exp Biol Med (Maywood). 2025 Jun 13;250:10606. doi: 10.3389/ebm.2025.10606. eCollection 2025.
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Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron.
Exp Biol Med (Maywood). 2024 Oct 28;249:10171. doi: 10.3389/ebm.2024.10171. eCollection 2024.
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Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.
Metab Brain Dis. 2023 Aug;38(6):2037-2053. doi: 10.1007/s11011-023-01218-2. Epub 2023 Apr 29.
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Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1.
Psychopharmacology (Berl). 2022 Sep;239(9):3031-3045. doi: 10.1007/s00213-022-06188-4. Epub 2022 Jul 20.
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Sevoflurane Exposure in the Developing Brain Induces Hyperactivity, Anxiety-Free, and Enhancement of Memory Consolidation in Mice.
Front Aging Neurosci. 2022 Jun 29;14:934230. doi: 10.3389/fnagi.2022.934230. eCollection 2022.

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2
Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia.
Neurotox Res. 2009 Aug;16(2):140-7. doi: 10.1007/s12640-009-9063-8. Epub 2009 May 27.
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Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice.
Anesthesiology. 2009 Mar;110(3):628-37. doi: 10.1097/ALN.0b013e3181974fa2.
6
Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model.
Neurosci Res. 2009 Mar;63(3):184-93. doi: 10.1016/j.neures.2008.12.002. Epub 2008 Dec 11.
9
Spatial relational memory requires hippocampal adult neurogenesis.
PLoS One. 2008 Apr 9;3(4):e1959. doi: 10.1371/journal.pone.0001959.
10
Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology.
Behav Pharmacol. 2007 Sep;18(5-6):521-31. doi: 10.1097/FBP.0b013e3282d28f83.

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