早期唇鳞状细胞癌：澳大利亚的经验以及放疗在改善高风险患者切除术后结局方面的益处。
Early-stage squamous cell carcinoma of the lip: the Australian experience and the benefits of radiotherapy in improving outcome in high-risk patients after resection.
机构信息
Head and Neck Cancer Service, Crown Princess Mary Cancer Centre, University of Sydney, Westmead, Sydney, Australia.
出版信息
Head Neck. 2013 Oct;35(10):1426-30. doi: 10.1002/hed.23148. Epub 2012 Sep 10.
BACKGROUND
The purpose of this study was to analyze the outcome of Australian patients treated for early lip cancer.
METHODS
Data on 217 patients with T1 to T2 squamous cell carcinoma (SCC) of the lip and treated with radical intent were analyzed.
RESULTS
The addition of local adjuvant radiotherapy in patients with a close/positive margin was associated with a significant improvement in relapse-free survival (RFS; p = .008). Tumor thickness (≤4 mm vs >4 mm) was also significantly associated with RFS (p = .01). The 5-year RFS was 51% after surgery, 87% after radiotherapy, and 92% after adjuvant radiotherapy.
CONCLUSIONS
Patients with a tumor thickness >4 mm experienced an increased risk of recurrence, especially nodal. Compared with patients having any radiotherapy, those undergoing surgery experienced a higher rate of locoregional recurrence. The addition of adjuvant radiotherapy in patients with inadequate excision significantly decreased the risk of recurrence.
背景
本研究旨在分析澳大利亚早期唇癌患者的治疗结果。
方法
分析了 217 例 T1 至 T2 期鳞状细胞癌（SCC）唇癌患者的资料，这些患者均接受根治性治疗。
结果
对于切缘接近/阳性的患者，局部辅助放疗可显著改善无复发生存率（RFS；p =.008）。肿瘤厚度（≤4mm 与＞4mm）也与 RFS 显著相关（p =.01）。单纯手术后 5 年 RFS 为 51%，单纯放疗后为 87%，辅助放疗后为 92%。
结论
肿瘤厚度＞4mm 的患者复发风险增加，尤其是淋巴结转移。与任何放疗患者相比，接受手术的患者局部区域复发率更高。对于切除不充分的患者，辅助放疗可显著降低复发风险。
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