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Pirenperone does not attenuate morphine analgesia in spinal rats.

作者信息

Paul D, Pinel J P

机构信息

Department of Psychology, University of British Columbia, Vancouver, Canada.

出版信息

Psychopharmacology (Berl). 1990;100(1):98-101. doi: 10.1007/BF02245797.

DOI:10.1007/BF02245797
PMID:2296631
Abstract

The selective serotonin type-2 (S2) receptor blocker pirenperone (0.24 mg/kg, SC) attenuates morphine-produced tail-flick antinociception in intact rats, but not in rats with transected spinal cords. These results suggest that S2 receptor blockade does not affect intraspinal opioid antinociception. Together with evidence that there are virtually no S2 receptors in the dorsal spinal cord, supraspinal S2 receptors are implicated in the mediation of morphine-produced antinociception.

摘要

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本文引用的文献

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Spinal vs supraspinal actions of morphine on cat spinal cord multireceptive neurons.吗啡对猫脊髓多感受神经元的脊髓与脊髓上作用
Brain Res. 1983 Aug 22;273(1):1-7. doi: 10.1016/0006-8993(83)91087-9.
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Characterization of multiple [3H]5-hydroxytryptamine binding sites in rat spinal cord tissue.
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Spinal serotonin (5-HT) receptor subtypes and nociception.脊髓5-羟色胺（5-HT）受体亚型与伤害感受
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Autoradiographic evidence for the heterogeneity of 5-HT1 sites in the rat brain.大鼠脑中5-HT1位点异质性的放射自显影证据。
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