Bartholomeusz Cali F, Allott Kelly
Melbourne Neuropsychiatry Centre, Department of Psychiatry, National Neuroscience Facility, The University of Melbourne, Level 2-3 Alan Gilbert Building, 161 Barry Street, Carlton South, VIC 3053, Australia.
Schizophr Res Treatment. 2012;2012:815315. doi: 10.1155/2012/815315. Epub 2012 Apr 5.
Improving functional outcome, in addition to alleviating psychotic symptoms, is now a major treatment objective in schizophrenia research. Given the large body of evidence suggesting pharmacological treatments generally have minimal effects on indices of functioning, research has turned to psychosocial rehabilitation programs. Among these, neurocognitive and social cognitive interventions are at the forefront of this field and are argued to target core deficits inherent to the schizophrenia illness. However, to date, research trials have primarily focused on chronic schizophrenia populations, neglecting the early psychosis groups who are often as severely impaired in social and occupational functioning. This theoretical paper will outline the rationale for investigating adjunctive cognitive-based interventions in the early phases of psychotic illness, critically examine the current approach strategies used in these interventions, and assess the evidence supporting certain training programs for improving functional outcome in early psychosis. Potential pathways for future research will be discussed.
除了缓解精神症状外,改善功能结局现在是精神分裂症研究的一个主要治疗目标。鉴于大量证据表明药物治疗通常对功能指标影响甚微,研究已转向心理社会康复项目。其中,神经认知和社会认知干预处于该领域前沿,并被认为针对精神分裂症疾病固有的核心缺陷。然而,迄今为止,研究试验主要集中在慢性精神分裂症患者群体,而忽视了早期精神病患者群体,这些患者在社会和职业功能方面往往同样严重受损。这篇理论文章将概述在精神病性疾病早期阶段研究辅助性认知干预措施的基本原理,批判性地审视这些干预措施中目前使用的方法策略,并评估支持某些训练项目以改善早期精神病功能结局的证据。还将讨论未来研究的潜在途径。