[腋窝淋巴结清扫数量对腋窝淋巴结阴性原发性乳腺癌预后的影响]

[Influence of the number of removed axillary lymph nodes on the prognosis of node-negative primary breast cancer].

作者信息

Wang Hui-ying, Dong Hui-ting, Liu Qun, Xing Peng, Li Ji-guang

机构信息

Department of Breast Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2012 Jun;34(6):457-60.

PMID:22967449

Abstract

OBJECTIVE

To analyze the relationship between the number of removed axillary lymph nodes and prognosis of axillary node-negative breast cancer.

METHODS

The clinicopathological data of 655 patients with breast cancer were analyzed retrospectively. The disease-free survival curves were generated according to the number of removed axillary lymph nodes using Kaplan-Meier plots. The correlation between the co-variables and rate of breast cancer-related events was analyzed using Cox model.

RESULTS

The overall five year-disease free survival rate of the 655 cases was 94.4%. The rate of patients with lymph node number ≤ 12 was 90.3%, and that of lymph node number > 12 was 96.5%, with a statistically significant difference (P = 0.009). Significantly less breast cancer-related events were observed in patients with lymph node number > 12 (15/426, 3.5%) than that in patients with lymph node number ≤ 12 (22/229, 9.6%) (P = 0.009).

CONCLUSIONS

When axillary node dissection is indicated, dissection of lymph nodes >12 leads to much less breast cancer-related events than that in patients with dissected lymph node ≤ 12. The more lymph nodes are dissected, the more accurate prognosis can be estimated.

摘要

目的

分析腋窝淋巴结清扫数目与腋窝淋巴结阴性乳腺癌预后的关系。

方法

回顾性分析655例乳腺癌患者的临床病理资料。采用Kaplan-Meier法根据腋窝淋巴结清扫数目绘制无病生存曲线。采用Cox模型分析各协变量与乳腺癌相关事件发生率之间的相关性。

结果

655例患者总的5年无病生存率为94.4%。腋窝淋巴结数目≤12个患者的5年无病生存率为90.3%，腋窝淋巴结数目>12个患者的5年无病生存率为96.5%，差异有统计学意义（P = 0.009）。腋窝淋巴结数目>12个患者发生乳腺癌相关事件的比例（15/426，3.5%）明显低于腋窝淋巴结数目≤12个患者（22/229，9.6%）（P = 0.009）。