University of Leipzig, Department of Medical Psychology and Medical Sociology, Philipp-Rosenthal-Str 55, 04103 Leipzig, Germany.
J Clin Psychiatry. 2012 Aug;73(8):1141-6. doi: 10.4088/JCP.11m07598.
Although depression is the strongest predictor for the full spectrum of suicidal ideation, several other mental disorders, eg, posttraumatic stress disorder (PTSD), are associated with suicidal ideation too. This study investigates whether suicidal ideation is specifically associated with PTSD or if this association is fully or partially mediated by comorbid depressive disorders.
A representative sample of 1,659 people aged 60-85 years from the German general population was examined by using self-rating instruments for PTSD, depression, and suicidal ideation in May and June 2008 in a cross-sectional study. Participants were diagnosed with PTSD when they met criteria A, B, C, and D for PTSD according to DSM-IV-TR. Suicidal ideation was used as the primary outcome measure.
In our sample, 7.3% of subjects reported suicidal ideation within the last 2 weeks. Suicidal ideation was associated with a higher number of traumatic experiences (mean = 1.13 vs 0.78; t = -3.20; P ≤ .001) and prevalence of PTSD (12.4% vs 3.4%, χ2 = 23.39, P < .001) than in subjects without suicidal ideation. In logistic regression analyses including age and sex, traumatic experiences were associated with suicidal ideation (OR = 1.16, P = .011). After including PTSD in the model, this association was fully explained by PTSD. Moreover, PTSD was associated with suicidal ideation (OR = 3.33, P < .001), but after including depression in the model, the association of PTSD and suicidal ideation was fully mediated by depression (OR = 1.61, P < .001).
The results of our study indicate that PTSD is associated with suicidal ideation, but this association was fully explained by comorbid depressive symptoms in the elderly general population. Thus, screening for depressive symptoms as well as administering an appropriate therapy seems the best way to prevent suicide attempts in the elderly, even in those patients with traumatic experiences and/or PTSD.
尽管抑郁是预测各种自杀意念的最强因素,但其他几种精神障碍,如创伤后应激障碍(PTSD),也与自杀意念有关。本研究旨在探讨自杀意念是否与 PTSD 有特定关联,还是这种关联完全或部分由共患的抑郁障碍所介导。
采用横断面研究,于 2008 年 5 月至 6 月使用自评工具对来自德国一般人群的 1659 名 60-85 岁人群进行调查,评估 PTSD、抑郁和自杀意念。根据 DSM-IV-TR,当参与者符合 PTSD 的 A、B、C 和 D 标准时,即可被诊断为 PTSD。自杀意念被用作主要结局指标。
在我们的样本中,7.3%的受试者在过去 2 周内报告有自杀意念。与无自杀意念者相比,有自杀意念者经历过更多的创伤事件(平均值=1.13 对 0.78;t=-3.20;P≤.001)和 PTSD 的患病率更高(12.4%对 3.4%,χ2=23.39,P<.001)。在包括年龄和性别在内的逻辑回归分析中,创伤经历与自杀意念相关(OR=1.16,P=.011)。在将 PTSD 纳入模型后,这种关联完全由 PTSD 解释。此外,PTSD 与自杀意念相关(OR=3.33,P<.001),但在将抑郁纳入模型后,PTSD 与自杀意念的关联完全由抑郁介导(OR=1.61,P<.001)。
本研究结果表明,PTSD 与自杀意念相关,但在老年人群中,这种关联完全由共患的抑郁症状所解释。因此,筛查抑郁症状并给予适当的治疗似乎是预防老年人自杀企图的最佳方法,即使是在那些有创伤经历和/或 PTSD 的患者中也是如此。