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原发性干燥综合征患者的III型膜增生性肾小球肾炎。

Type III membranoproliferative glomerulonephritis in a patient with primary Sjögren's syndrome.

作者信息

Sun In O, Hong Yu Ah, Park Hoon Suk, Choi Sun Ryoung, Kang Seok Hui, Chung Byung Ha, Choi Bum Soon, Choi Yeong Jin, Yang Chul Woo, Kim Yong Soo, Park Cheol Whee

机构信息

Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea.

出版信息

Clin Nephrol. 2013 Feb;79(2):171-4. doi: 10.5414/CN107283.

Abstract

Renal involvement in the form of glomerulonephritis in Sjögren's syndrome (SS) is less common and usually a latent sequel in the course of the disease. We report a patient with Type III membarnoproliferative glomerulonephritis (MPGN) with hypothyroidism, which precedes the onset of the clinical manifestation of SS. She received immunosuppressions consisting of i.v. cyclophosphamide and high-dose corticosteroid and subsequently oral corticosteroid resulting in complete remission of nephrotic syndrome. To our knowledge, this is the first report of successfully treated Type III MPGN associated with SS.

摘要

干燥综合征(SS)中以肾小球肾炎形式出现的肾脏受累较为少见,通常是疾病过程中的潜在后遗症。我们报告一例患有III型膜增生性肾小球肾炎(MPGN)并伴有甲状腺功能减退的患者,该患者在SS临床表现出现之前就已患病。她接受了包括静脉注射环磷酰胺和大剂量皮质类固醇,随后口服皮质类固醇的免疫抑制治疗,肾病综合征完全缓解。据我们所知,这是首例成功治疗的与SS相关的III型MPGN报告。

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