Tristetraprolin/TIS11 RNA 结合蛋白在调节 mRNA 生成和降解中的多种功能。
Multiple functions of tristetraprolin/TIS11 RNA-binding proteins in the regulation of mRNA biogenesis and degradation.
机构信息
Institut National de la Santé et de la Recherche Médicale (INSERM) U1036, 17 rue des Martyrs, 38054, Grenoble Cedex 9, France.
出版信息
Cell Mol Life Sci. 2013 Jun;70(12):2031-44. doi: 10.1007/s00018-012-1150-y. Epub 2012 Sep 12.
Abstract
Members of the tristetraprolin (TTP/TIS11) family are important RNA-binding proteins initially characterized as mediators of mRNA degradation. They act via their interaction with AU-rich elements present in the 3'UTR of regulated transcripts. However, it is progressively appearing that the different steps of mRNA processing and fate including transcription, splicing, polyadenylation, translation, and degradation are coordinately regulated by multifunctional integrator proteins that possess a larger panel of functions than originally anticipated. Tristetraprolin and related proteins are very good examples of such integrators. This review gathers the present knowledge on the functions of this family of RNA-binding proteins, including their role in AU-rich element-mediated mRNA decay and focuses on recent advances that support the concept of their broader involvement in distinct steps of mRNA biogenesis and degradation.
摘要
Tristetraprolin（TTP/TIS11）家族成员是重要的 RNA 结合蛋白，最初被认为是介导 mRNA 降解的介质。它们通过与调节转录物 3'UTR 中存在的富含 AU 的元件相互作用而发挥作用。然而，越来越明显的是，mRNA 处理和命运的不同步骤，包括转录、剪接、多聚腺苷酸化、翻译和降解，都受到多功能整合蛋白的协调调节，这些整合蛋白具有比最初预期更多的功能。Tristetraprolin 和相关蛋白就是这种整合蛋白的很好的例子。这篇综述汇集了该家族 RNA 结合蛋白功能的现有知识，包括它们在富含 AU 的元件介导的 mRNA 衰变中的作用，并侧重于支持其更广泛参与 mRNA 生物发生和降解的不同步骤的最新进展。
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