Shchudlo N A, Borisova I V, Krasnov V V, Dobychina N A
Stomatologiia (Mosk). 2012;91(3):4-6.
Fracture of mandibular body at the level of P3-P4 with symphysis rupture was modeled, reposition and transosseous osteosynthesis with a specially developed device were performed under anesthesia in the operating room in 17 adult mongrel dogs in order to specify the pathogenesis and the dynamics of injury and jaw nerve regeneration. It has been established, that the arrangement of the neurovascular bundle in medullary canal predetermines the development of acute and chronic compression-and-ischemic neuropathy even if accurate reposition of bone fragments takes place. The histological signs of nerve fiber regeneration, the loss of the quantity of myelin-free nerve conductors and the retrograde spreading of degenerative changes in myelinized nerve conductors, including regenerating ones, have been found beginning from 4 weeks after injury. It has been concluded, that spontaneous nerve regeneration in case of mandibular fractures should be actively supported by neuroprotective, anti-edematous and anti-inflammatory therapy.
在17只成年杂种犬身上建立了下颌骨体部P3 - P4水平骨折伴联合部破裂的模型，在手术室麻醉下使用专门研制的装置进行骨折复位和穿骨内固定，以明确损伤的发病机制、动态变化以及颌神经再生情况。已经确定，即使骨碎片准确复位，髓腔内神经血管束的排列也会预先决定急性和慢性压迫性缺血性神经病变的发展。从损伤后4周开始，发现了神经纤维再生的组织学迹象、无髓神经传导束数量的减少以及有髓神经传导束（包括再生的传导束）退行性变化的逆行扩散。得出的结论是，在下颌骨骨折的情况下，应通过神经保护、抗水肿和抗炎治疗积极支持神经的自发再生。
