仿生氧化偶联苄胺和 2-氨基酚：苯并恶唑的合成。
Biomimetic oxidative coupling of benzylamines and 2-aminophenols: synthesis of benzoxazoles.
机构信息
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
出版信息
Chemistry. 2012 Oct 22;18(43):13609-13. doi: 10.1002/chem.201202187. Epub 2012 Sep 11.
PMID:22968931
Abstract
Aerobic oxidation: in a biomimetic approach, a mixture of redox catalysts forms couples that effect the aerobic oxidation of a mixture of benzylamine and 2-aminophenol derivatives to give the corresponding benzoxazoles. This biomimetic oxidation proceeds smoothly under mild conditions and the protocol can also be used for preparing benzimidazoles and benzothiazoles.
摘要
有氧氧化
在仿生方法中，氧化还原催化剂的混合物形成偶联物，使苄胺和 2-氨基苯酚衍生物的混合物有氧氧化生成相应的苯并恶唑。该仿生氧化在温和条件下顺利进行，该方案也可用于制备苯并咪唑和苯并噻唑。
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