重新审视核仁：从标志物到癌症信号的动态整合者。
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling.
机构信息
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
出版信息
Sci Signal. 2012 Sep 11;5(241):pe38. doi: 10.1126/scisignal.2003477.
Abstract
Key signaling pathways (such as phosphoinositide 3-kinase, Myc, and RAS) act as sensors of energy, stress, and nutrient availability and integrate these inputs to directly control ribosome production and gene expression at the translational level. This activity is normally directly coupled to cell growth, division, and survival. However, it remains poorly understood the extent to which changes in ribosome number and nucleolar integrity downstream of these key signaling pathways contribute to their oncogenic activity. Emerging studies provide interesting insight into how deregulations in RNA polymerase I activity may lead to tumorigenesis and suggest that new drugs targeting ribosomal DNA transcription may hold great promise for the treatment of cancer.
摘要
关键信号通路（如磷酸肌醇 3-激酶、Myc 和 RAS）充当能量、应激和营养可用性的传感器，并整合这些输入，直接在翻译水平上控制核糖体的产生和基因表达。这种活性通常与细胞生长、分裂和存活直接相关。然而，这些关键信号通路下游的核糖体数量和核仁完整性的变化在多大程度上促进其致癌活性，目前仍知之甚少。新兴的研究为 RNA 聚合酶 I 活性的失调如何导致肿瘤发生提供了有趣的见解，并表明靶向核糖体 DNA 转录的新药可能为癌症治疗带来巨大希望。
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