早期给予支链氨基酸颗粒。
Early administration of branched-chain amino acid granules.
机构信息
Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950-1104, Japan.
出版信息
World J Gastroenterol. 2012 Sep 7;18(33):4486-90. doi: 10.3748/wjg.v18.i33.4486.
Abstract
The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been well defined. Nutritional intervention with branched-chain amino acid (BCAA) can increase serum albumin concentration in patients with decompensated cirrhosis but its effects on survival are unclear. The BCAA to tyrosine ratio (BTR) is a surrogate marker (the normal range of BTR is between 4.41 and 10.05, and a Fischer's ratio of 1.8 corresponds to a BTR of 3.5) in patients with decompensated liver cirrhosis, and BCAA inhibits hepatic carcinogenesis in patients with compensated cirrhosis. This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis.
摘要
营养不良对失代偿期肝硬化患者生存的影响尚未明确。给予支链氨基酸（BCAA）的营养干预可以增加失代偿期肝硬化患者的血清白蛋白浓度，但对生存的影响尚不清楚。BCAA 与酪氨酸的比值（BTR）是失代偿期肝硬化患者的替代标志物（BTR 的正常范围为 4.41 至 10.05，Fischer 比值为 1.8 对应 BTR 为 3.5），BCAA 抑制代偿期肝硬化患者的肝致癌作用。本综述讨论了根据 BCAA 与 BTR 的比值早期给予 BCAA 颗粒对肝硬化患者预后影响的数据。
相似文献
1
Early administration of branched-chain amino acid granules.
World J Gastroenterol. 2012 Sep 7;18(33):4486-90. doi: 10.3748/wjg.v18.i33.4486.
2
Impact of the branched-chain amino acid to tyrosine ratio and branched-chain amino acid granule therapy in patients with hepatocellular carcinoma: A propensity score analysis.
J Gastroenterol Hepatol. 2015 Sep;30(9):1412-9. doi: 10.1111/jgh.12954.
3
Easy clinical predictor for low BCAA to tyrosine ratio in chronic liver disease patients with hepatocellular carcinoma: Usefulness of ALBI score as nutritional prognostic marker.
Cancer Med. 2021 Jun;10(11):3584-3592. doi: 10.1002/cam4.3908. Epub 2021 May 7.
4
Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis.
Clin Gastroenterol Hepatol. 2005 Jul;3(7):705-13. doi: 10.1016/s1542-3565(05)00017-0.
5
Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis.
Hepatogastroenterology. 2009 Nov-Dec;56(96):1719-23.
6
Evaluating response to nutritional therapy using the branched-chain amino acid/tyrosine ratio in patients with chronic liver disease.
J Clin Lab Anal. 1999;13(1):31-4. doi: 10.1002/(SICI)1098-2825(1999)13:1<31::AID-JCLA6>3.0.CO;2-Y.
7
8
Branched-chain amino acids as a protein- and energy-source in liver cirrhosis.
Biochem Biophys Res Commun. 2004 Jan 9;313(2):405-9. doi: 10.1016/j.bbrc.2003.07.016.
9
Oral branched-chain amino acid granules reduce the incidence of hepatocellular carcinoma and improve event-free survival in patients with liver cirrhosis.
Dig Dis. 2011;29(3):326-32. doi: 10.1159/000327571. Epub 2011 Aug 9.
10
Effect of oral supplementation with branched-chain amino acid granules in the early stage of cirrhosis.
Hepatol Res. 2004 Dec;30S:36-41. doi: 10.1016/j.hepres.2004.08.009. Epub 2004 Nov 10.
引用本文的文献
1
The Role of Branched-Chain Amino Acid Supplementation in Combination with Locoregional Treatments for Hepatocellular Carcinoma: Systematic Review and Meta-Analysis.
Cancers (Basel). 2023 Feb 1;15(3):926. doi: 10.3390/cancers15030926.
2
Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases.
Clin Mol Hepatol. 2022 Jul;28(3):425-472. doi: 10.3350/cmh.2022.0186. Epub 2022 Jul 1.
3
Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment.
Hepat Mon. 2016 May 23;16(6):e35824. doi: 10.5812/hepatmon.35824. eCollection 2016 Jun.
4
Effect of branched-chain amino acids in patients receiving intervention for hepatocellular carcinoma.
World J Gastroenterol. 2014 Mar 14;20(10):2673-80. doi: 10.3748/wjg.v20.i10.2673.
5
Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour.
Reprod Biol Endocrinol. 2014 Jan 3;12:2. doi: 10.1186/1477-7827-12-2.
本文引用的文献
1
Branched-chain amino acids to tyrosine ratio value as a potential prognostic factor for hepatocellular carcinoma.
World J Gastroenterol. 2012 May 7;18(17):2005-8. doi: 10.3748/wjg.v18.i17.2005.
2
Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma.
World J Gastroenterol. 2012 Mar 28;18(12):1379-84. doi: 10.3748/wjg.v18.i12.1379.
3
Late-evening snack with branched-chain amino acids improves liver function after radiofrequency ablation for hepatocellular carcinoma.
Hepatol Res. 2012 Jul;42(7):658-67. doi: 10.1111/j.1872-034X.2012.00969.x. Epub 2012 Mar 2.
4
Anti-hypoalbuminemic effect of branched-chain amino acid granules in patients with liver cirrhosis is independent of dietary energy and protein intake.
Hepatol Res. 2011 Nov;41(11):1027-35. doi: 10.1111/j.1872-034X.2011.00864.x. Epub 2011 Sep 22.
5
Oral branched-chain amino acid granules reduce the incidence of hepatocellular carcinoma and improve event-free survival in patients with liver cirrhosis.
Dig Dis. 2011;29(3):326-32. doi: 10.1159/000327571. Epub 2011 Aug 9.
6
Branched-chain amino acids as pharmacological nutrients in chronic liver disease.
Hepatology. 2011 Sep 2;54(3):1063-70. doi: 10.1002/hep.24412. Epub 2011 Jun 23.
7
Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study.
Cancer Res Treat. 2011 Mar;43(1):24-31. doi: 10.4143/crt.2011.43.1.24. Epub 2011 Mar 31.
8
Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial.
J Gastroenterol Hepatol. 2010 Sep;25(9):1550-5. doi: 10.1111/j.1440-1746.2010.06306.x.
9
Prospective randomized controlled study of short-term perioperative oral nutrition with branched chain amino acids in patients undergoing liver surgery.
Hepatogastroenterology. 2010 May-Jun;57(99-100):583-90.
10
Effect of a late evening snack using branched-chain amino acid-enriched nutrients in patients undergoing hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma.
Hepatol Res. 2010 Jun;40(6):574-84. doi: 10.1111/j.1872-034X.2010.00665.x.
Zotero 插件