Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950-1104, Japan.
World J Gastroenterol. 2012 Sep 7;18(33):4486-90. doi: 10.3748/wjg.v18.i33.4486.
The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been well defined. Nutritional intervention with branched-chain amino acid (BCAA) can increase serum albumin concentration in patients with decompensated cirrhosis but its effects on survival are unclear. The BCAA to tyrosine ratio (BTR) is a surrogate marker (the normal range of BTR is between 4.41 and 10.05, and a Fischer's ratio of 1.8 corresponds to a BTR of 3.5) in patients with decompensated liver cirrhosis, and BCAA inhibits hepatic carcinogenesis in patients with compensated cirrhosis. This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis.
营养不良对失代偿期肝硬化患者生存的影响尚未明确。给予支链氨基酸（BCAA）的营养干预可以增加失代偿期肝硬化患者的血清白蛋白浓度，但对生存的影响尚不清楚。BCAA 与酪氨酸的比值（BTR）是失代偿期肝硬化患者的替代标志物（BTR 的正常范围为 4.41 至 10.05，Fischer 比值为 1.8 对应 BTR 为 3.5），BCAA 抑制代偿期肝硬化患者的肝致癌作用。本综述讨论了根据 BCAA 与 BTR 的比值早期给予 BCAA 颗粒对肝硬化患者预后影响的数据。
