Sasaki Hidefumi, Yokota Keisuke, Hikosaka Yu, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka
Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Exp Ther Med. 2012 Jan;3(1):44-48. doi: 10.3892/etm.2011.374. Epub 2011 Oct 21.
The transcription factor Sox2 is necessary for foregut morphogenesis. Sox2 is also required for the normal development of the trachea and lung. Recently, Sox2 amplifications were investigated using large-scale single nucleotide polymorphism arrays in esophageal and lung cancer. We hypothesized that Sox2 overexpression might be correlated with clinicopathological features of lung cancers. The increased copy number of the Sox2 gene was analyzed by real-time polymerase chain reaction amplifications in 127 surgically treated non-small cell lung cancer cases from Nagoya City University Hospital, Japan. A total of 87 squamous cell carcinoma (SCC) cases were involved. An increased Sox2 gene copy number was found in 42 (33.1%) lung cancer patients. Increased Sox2 copy number status was significantly correlated with gender (females, 9.5% vs. males, 34.1%; p=0.0026), smoking status (never smoker, 4.8% vs. smoker, 32.9%; p=0.0003) and pathological subtypes (squamous cell carcinoma, 44.8% vs. non-squamous cell carcinoma, 7.5%; p<0.0001). However, among the SCCs, the Sox2 copy number status was not significantly correlated with gender, smoking status, pathological stage or differentiation status. An increased Sox2 copy number is common within SCC.
转录因子Sox2对前肠形态发生是必需的。Sox2对气管和肺的正常发育也很重要。最近，利用大规模单核苷酸多态性阵列对食管癌和肺癌中的Sox2扩增进行了研究。我们假设Sox2过表达可能与肺癌的临床病理特征相关。通过实时聚合酶链反应扩增，对来自日本名古屋市立大学医院的127例接受手术治疗的非小细胞肺癌病例的Sox2基因拷贝数增加情况进行了分析。其中共有87例鳞状细胞癌（SCC）病例。在42例（33.1%）肺癌患者中发现Sox2基因拷贝数增加。Sox2拷贝数增加状态与性别（女性为9.5%，男性为34.1%；p=0.0026）、吸烟状态（从不吸烟者为4.8%，吸烟者为32.9%；p=0.0003）和病理亚型（鳞状细胞癌为44.8%，非鳞状细胞癌为7.5%；p<0.0001）显著相关。然而，在SCC中，Sox2拷贝数状态与性别、吸烟状态、病理分期或分化状态均无显著相关性。Sox2拷贝数增加在SCC中很常见。
