生存素表达的意义：Ⅲ期非小细胞肺癌的预后价值与生存情况
Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer.
作者信息
Wang Meng, Liu Bao-Gang, Yang Zhao-Yang, Hong Xuan, Chen Gong-Yan
机构信息
Department of Respiratory Medicine, The Third Affiliated Hospital of Harbin Medical University, Harbin 150086, P.R. China.
出版信息
Exp Ther Med. 2012 Jun;3(6):983-988. doi: 10.3892/etm.2012.512. Epub 2012 Mar 12.
Abstract
This study was designed to determine the levels of survivin expression and identify its clinical significance as a prognostic factor for stage III non-small cell lung cancer (NSCLC). A total of 210 cases of stage III NSCLC were collected and the expression levels of survivin and vascular endothelial growth factor A (VEGF-A) in tumor tissues were investigated using immunohistochemistry (IHC). The medical records of the patients were reviewed to determine the association with clinical course. Of the 210 NSCLC tissues, 112 (53.3%) cases demonstrated positive expression of survivin protein. Coexpression of survivin and VEGF-A was identified. The 5-year survival rate of patients with positive survivin expression was significantly lower compared with the survivin-negative cancer patients (P<0.05). The expression of survivin in NSCLC correlated with tumor size. Survivin and VEGF-A were independent prognostic factors of stage III NSCLC. Survivin protein is a valuable marker of prognosis in stage III NSCLC patients.
摘要
本研究旨在确定生存素的表达水平，并确定其作为Ⅲ期非小细胞肺癌（NSCLC）预后因素的临床意义。共收集210例Ⅲ期NSCLC病例，采用免疫组织化学（IHC）方法检测肿瘤组织中生存素和血管内皮生长因子A（VEGF-A）的表达水平。回顾患者的病历以确定其与临床病程的相关性。在210例NSCLC组织中，112例（53.3%）生存素蛋白呈阳性表达。发现生存素与VEGF-A共表达。生存素表达阳性患者的5年生存率显著低于生存素阴性的癌症患者（P<0.05）。NSCLC中生存素的表达与肿瘤大小相关。生存素和VEGF-A是Ⅲ期NSCLC的独立预后因素。生存素蛋白是Ⅲ期NSCLC患者预后的一个有价值的标志物。
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