Croxatto H R, Zamorano B, Rojas M, Arriagada R
Adv Exp Med Biol. 1979;120B:437-45.
It is confirmed that urinary kallikrein is significantly and persistently decreased in totally hypophysectomized rats. In addition, kallikrein activity in the kidneys in these animals is significantly reduced (p less than .001) as compared to partially hypophysectomized and sham-operated rats. The administration of 125 mU of ACTH twice a day for 2 months, did not modify urinary kallikrein excretion. Negative effects were also obtained in subsequent periods, by injection of 10 microgram corticosterone and 10 microgram aldosterone, twice a day for 9 and 6 days, respectively. The administration of rat pituitary anterior lobe homogenates, freshly prepared, increased significantly urinary kallikrein level in hypophysectomized rats.
已证实，在完全垂体切除的大鼠中，尿激肽释放酶显著且持续减少。此外，与部分垂体切除和假手术的大鼠相比，这些动物肾脏中的激肽释放酶活性显著降低（p小于0.001）。每天两次给予125 mU促肾上腺皮质激素，持续2个月，并未改变尿激肽释放酶的排泄。在随后的时期，分别每天两次注射10微克皮质酮和10微克醛固酮，持续9天和6天，也得到了负面效果。给予新鲜制备的大鼠垂体前叶匀浆，可显著提高垂体切除大鼠的尿激肽释放酶水平。
