Xue Y-Y, Wang H-N, Xue F, Tan Q-R
Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
J Int Med Res. 2012;40(4):1467-75. doi: 10.1177/147323001204000425.
To investigate the effects of atypical antipsychotics on prepulse inhibition, startle response and habituation in acutely psychotic patients with schizophrenia, and investigate whether prepulse inhibition deficit improvements are a result of the direct impact of atypical antipsychotics or improvements in antipsychotic-related symptoms.
Prepulse inhibition, habituation and acoustic startle response were evaluated in healthy control subjects and patients with schizophrenia (either unmedicated with antipsychotics at the time of hospitalization or medicated with atypical antipsychotics for ≥1 month before hospitalization).
Data were analysed for 26 patients in the unmedicated group, 20 patients in the medicated group and 31 control subjects. Compared with controls, both medicated and unmedicated patients showed prepulse inhibition deficits; however, there were no significant differences between the two patient groups. Lower prepulse inhibition levels were correlated with higher levels of positive, negative, general and total scores on the Positive and Negative Syndrome Scale.
These results suggest that effects of atypical antipsychotics on prepulse inhibition may not be evident when patients with schizophrenia are acutely symptomatic, and do not directly influence prepulse inhibition.
研究非典型抗精神病药物对急性精神分裂症患者的前脉冲抑制、惊吓反应和习惯化的影响，并探究前脉冲抑制缺陷的改善是由于非典型抗精神病药物的直接作用还是抗精神病相关症状的改善。
对健康对照者和精神分裂症患者（住院时未服用抗精神病药物或住院前服用非典型抗精神病药物≥1个月）进行前脉冲抑制、习惯化和声惊吓反应评估。
分析了未服药组26例患者、服药组20例患者和31名对照者的数据。与对照组相比，服药和未服药患者均表现出前脉冲抑制缺陷；然而，两组患者之间无显著差异。较低的前脉冲抑制水平与阳性和阴性症状量表上较高的阳性、阴性、一般和总分相关。
这些结果表明，当精神分裂症患者处于急性症状期时，非典型抗精神病药物对前脉冲抑制的影响可能不明显，且不会直接影响前脉冲抑制。
