Wu J, Yang L, Yang J, Yang C H, Zhang X H
Department of Radiology, The PLA General Hospital, Beijing, China.
J Int Med Res. 2012;40(4):1507-12. doi: 10.1177/147323001204000430.
Gender-specific normal concentrations of myocardial metabolites and the differences that might exist between healthy males and females were measured in vivo using 1H-magnetic resonance spectroscopy (1H-MRS).
A total of 100 healthy individuals (57 males, 43 females) were studied. Cardiac magnetic resonance imaging and localized 1H-MRS were used to localize the voxels and quantify myocardial metabolite concentrations, respectively, for each gender.
A total of 14 participants were excluded because of motion and poor spectra, which meant that 86 participants (46 males, 40 females) were included in the final analysis. Spectral peaks were identified with chemical shifts corresponding to water, choline, creatine and triglyceride. Myocardial choline and creatine levels showed no statistically significant differences between males and females. Females had a significantly lower body mass index and body surface area compared with males, and a significantly higher concentration of myocardial triglycerides.
Myocardial triglyceride concentration was shown to be related to gender, whereas myocardial creatine and choline concentrations were not gender-related.
使用氢磁共振波谱（1H-MRS）在体内测量心肌代谢物的性别特异性正常浓度以及健康男性和女性之间可能存在的差异。
共研究了100名健康个体（57名男性，43名女性）。心脏磁共振成像和局部1H-MRS分别用于定位体素并量化每种性别的心肌代谢物浓度。
共有14名参与者因运动和谱图不佳被排除，这意味着最终分析纳入了86名参与者（46名男性，40名女性）。通过与水、胆碱、肌酸和甘油三酯相对应的化学位移识别出光谱峰。男性和女性的心肌胆碱和肌酸水平无统计学显著差异。与男性相比，女性的体重指数和体表面积显著更低，心肌甘油三酯浓度显著更高。
心肌甘油三酯浓度显示与性别有关，而心肌肌酸和胆碱浓度与性别无关。
