2型糖尿病患者的血浆肾上腺髓质素与亚临床心肾综合征
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus.
作者信息
Pecková M, Charvat J, Schuck O, Zamrazil V, Bilek R, Hill M, Svab P, Horackova M
机构信息
Department of Medicine, University Hospital Motol, Second Medical School, Charles University, V Úvalu 84, 150 06 Prague 5, Czech Republic.
出版信息
J Int Med Res. 2012;40(4):1552-9. doi: 10.1177/147323001204000435.
OBJECTIVE
To evaluate whether plasma adrenomedullin is involved in the previously reported significant inverse correlation between left ventricular (LV) end-diastolic pressure (peak velocity of early transmitral flow/peak velocity of early diastolic mitral annular motion ratio [E/E' ]) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus, mild-to-moderate renal function impairment and LV relaxation impairment (E'≤7.1 cm/s).
METHODS
Plasma adrenomedullin concentration, E/E' and eGFR were assessed in 82 patients with type 2 diabetes.
RESULTS
Plasma adrenomedullin concentration was positively correlated with eGFR in patients with or without LV relaxation impairment, and inversely correlated with E/E' in patients with LV relaxation impairment. Multivariate linear regression analysis supported a role for plasma adrenomedullin in the association between E/E' and eGFR.
CONCLUSION
These results support the hypothesis that adrenomedullin modulates the interaction between the heart and kidneys in early subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus.
目的
评估血浆肾上腺髓质素是否参与了先前报道的2型糖尿病、轻至中度肾功能损害及左心室舒张功能障碍（E'≤7.1 cm/s）患者的左心室舒张末期压力（早期二尖瓣血流峰值速度/舒张早期二尖瓣环运动峰值速度比值[E/E']）与估算肾小球滤过率（eGFR）之间显著的负相关关系。
方法
对82例2型糖尿病患者的血浆肾上腺髓质素浓度、E/E'及eGFR进行评估。
结果
无论有无左心室舒张功能障碍，血浆肾上腺髓质素浓度均与eGFR呈正相关，而在有左心室舒张功能障碍的患者中，其与E/E'呈负相关。多变量线性回归分析支持血浆肾上腺髓质素在E/E'与eGFR之间的关联中起作用。
结论
这些结果支持以下假说：肾上腺髓质素在2型糖尿病患者早期亚临床心肾综合征中调节心脏与肾脏之间的相互作用。
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