Guo Changjuan, Gao Wei, Huang Zhengzu, Zhu Hui, Fu Zhong, Dong Junguo, Cheng Ping, Zhou Zhen
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China.
Eur J Mass Spectrom (Chichester). 2012;18(4):349-60. doi: 10.1255/ejms.1193.
We have described a home-made desktop orthogonal-injection time-of-flight (O-ToF) mass spectrometer combining a collisional cooling system. This O-ToF consists of a simple electrospray ion source, an atmosphere-vacuum interface, an area of transmission, including a radio-frequency only quadrupole (RF- only quadrupole, RFQ) as a collisional cooling cell and an orthogonal ToF mass analyzer. In order to detect ions of small m/z value, such as small metal ions, the RFQ has been improved to weaken the mass discrimination effect against low mass ions. Metal salt solutions were used in the experiment. The system has shown a satisfactory resolving power in the spectra (m/Δm = 3500), a good mass stability, a limit of detection of 80 fg and a mass accuracy of 48 ppm. The dynamic range is found to be from 10(-8) mol L(-1) to 10(-5) mol L(-1), allowing the semi-quantitative analysis of metal ions.
我们描述了一种结合碰撞冷却系统的自制台式正交注入飞行时间（O-ToF）质谱仪。这种O-ToF由一个简单的电喷雾离子源、一个大气-真空接口、一个传输区域组成，该传输区域包括一个仅作为碰撞冷却池的射频四极杆（RF-only quadrupole，RFQ）和一个正交ToF质量分析器。为了检测小m/z值的离子，如小金属离子，对RFQ进行了改进，以减弱对低质量离子的质量歧视效应。实验中使用了金属盐溶液。该系统在光谱中显示出令人满意的分辨率（m/Δm = 3500）、良好的质量稳定性、80 fg的检测限和48 ppm的质量准确度。发现动态范围为10(-8) mol L(-1)至10(-5) mol L(-1)，可对金属离子进行半定量分析。
