Sabater Marco Vicente, Navalón Verdejo Pedro, Morera Faet Arturo
Pathology Department, Consorcio, Hospital General Universitario, Hospital Casa Salud, Valencia, Spain.
Arch Esp Urol. 2012 Sep;65(7):709-13.
Inverted papilloma of the urinary bladder is an uncommon urothelial neoplasm that may be specially difficult to distinguish from urothelial carcinoma.
Two patients with obstructive symptoms and hematuria have been studied. In the transurethral resection, accidentally, one showed a papillary lesion in the context of nodular hyperplasia of the prostate, where as the other showed a polypoid tumor of the urinary bladder
Histologically, in both cases, a bladder inverted papilloma was demonstrated, originating from the surface transitional epithelium. Basal cells exhibited peripheral palisading pattern in the trabecular form. In the glandular type, Dogiel or umbrella cells into the gland-like structures, were recognized. Immunohistochemical stains for p53 and Ki-67 were negative. Umbrella cells were positive for cytokeratin 20.
Two cases of bladder inverted papilloma with relevant morphological aspects are presented, which we consider useful for the differential diagnosis with urothelial carcinoma.
膀胱内翻性乳头状瘤是一种罕见的尿路上皮肿瘤，可能特别难以与尿路上皮癌区分。
对两名有梗阻症状和血尿的患者进行了研究。在经尿道切除术中，意外地，一名患者在前列腺结节性增生的背景下出现乳头状病变，而另一名患者则表现为膀胱息肉样肿瘤。
组织学上，两例均证实为膀胱内翻性乳头状瘤，起源于表面移行上皮。基底细胞在小梁状结构中呈周边栅栏状排列。在腺型中，可见到多吉尔细胞或伞状细胞进入腺样结构。p53和Ki-67的免疫组化染色均为阴性。伞状细胞细胞角蛋白20呈阳性。
本文报告两例具有相关形态学特征的膀胱内翻性乳头状瘤，我们认为这对与尿路上皮癌的鉴别诊断有用。
