Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada.
Psychopharmacology (Berl). 2013 Feb;225(3):743-51. doi: 10.1007/s00213-012-2861-3. Epub 2012 Sep 13.
Depression is prevalent among women of childbearing age and is frequently treated with selective serotonin reuptake inhibitors (SSRIs). As some SSRIs, such as fluoxetine (Flx), can cross the placenta, it is possible that the neurodevelopment of the fetus may be affected, leading to altered behavior in adulthood.
In this study, we examined the effects of perinatal Flx exposure on the subsequent expression of circadian rhythms in adult mice.
Dams were treated with 25 mg/kg/day Flx in their drinking water from embryonic day 15 to postnatal day 12. Circadian organization of wheel running rhythms and phase shifts to photic and non-photic stimuli were assessed in the offspring starting at 6 weeks of age.
We found that perinatal Flx exposure led to larger light-induced phase advances (1.19 ± 0.51 vs. 0.55 ± 0.25 h), smaller phase advances to the serotonin agonist 8-OH-DPAT during the mid-subjective day (0.44 ± 0.15 vs. 0.70 ± 0.17 h), and a shorter free-running period in constant darkness (23.47 ± 0.13 vs. 23.64 ± 0.13 h).
These results suggest that perinatal exposure to SSRIs may have consequences for the functioning of the circadian system later in life.
生育年龄的女性中普遍存在抑郁症状，常采用选择性 5-羟色胺再摄取抑制剂（SSRIs）进行治疗。某些 SSRIs，如氟西汀（Flx），可以穿过胎盘，因此胎儿的神经发育可能会受到影响，导致成年后行为改变。
本研究旨在探讨围产期 Flx 暴露对成年小鼠随后的昼夜节律表达的影响。
从胚胎第 15 天到产后第 12 天，母鼠在饮用水中接受 25mg/kg/天的 Flx 治疗。从 6 周龄开始，评估后代的轮式跑步节律的昼夜节律组织和对光和非光刺激的相位转变。
我们发现，围产期 Flx 暴露导致更大的光诱导相位提前（1.19±0.51 与 0.55±0.25 小时），在主观日中期对 5-羟色胺激动剂 8-OH-DPAT 的相位提前较小（0.44±0.15 与 0.70±0.17 小时），在持续黑暗中的自由运行周期较短（23.47±0.13 与 23.64±0.13 小时）。
这些结果表明，围产期暴露于 SSRIs 可能对生命后期的昼夜节律系统功能产生影响。
