多细胞肿瘤球体中的低剂量辐射超敏感性。
Low-dose radiation hyper-radiosensitivity in multicellular tumour spheroids.
机构信息
Radiophysics Service, University Hospital San Cecilio, Granada, Spain.
出版信息
Br J Radiol. 2012 Oct;85(1018):1398-406. doi: 10.1259/bjr/33201506.
Abstract
OBJECTIVE
We propose and study a new model aimed at describing the low-dose hyper-radiosensitivity phenomenon appearing in the survival curves of different cell lines.
METHODS
The model uses the induced repair assumption, considering that the critical dose at which this mechanism begins to act varies from cell to cell in a given population. The model proposed is compared with the linear-quadratic model and the modified linear-quadratic model, which is commonly used in literature and in which the induced repair is taken into account in a heuristic way. The survival curve for the MCF-7 line of human breast cancer is measured at low absorbed doses and the uncertainties in these doses are estimated using thermoluminiscent dosemeters.
RESULTS
It is shown that these multicellular spheroids present low-dose hyper-radiosensitivity. The new model permits an accurate description of the data of two human cell lines (previously published) and of the multicellular spheroids of the MCF-7 line here measured.
CONCLUSION
The model shows enough flexibility to account for data with very different characteristics and considers in a faithful way the hypothesis of the repair induction.
摘要
目的
我们提出并研究了一个新的模型，旨在描述不同细胞系生存曲线中出现的低剂量超敏感性现象。
方法
该模型采用诱导修复假设，认为在给定群体中，该机制开始作用的临界剂量因细胞而异。所提出的模型与线性二次模型和常用文献中的修正线性二次模型进行了比较，后两者以启发式方式考虑了诱导修复。用人乳腺癌 MCF-7 系的生存曲线在低吸收剂量下进行测量，并使用热释光剂量计估计这些剂量的不确定度。
结果
结果表明，这些多细胞球体呈现低剂量超敏感性。新模型可以准确描述两个人类细胞系（先前发表的）和此处测量的 MCF-7 系多细胞球体的数据。
结论
该模型具有足够的灵活性，可以解释具有非常不同特征的数据，并忠实地考虑了修复诱导的假设。
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