Hong C Z, Cheng B B, Liú A Y, Yu J
University of California, Irvine Medical Center, Orange.
Arch Phys Med Rehabil. 1990 Jan;71(1):42-5.
This study was designed to investigate the effectiveness of local steroid injection on the recovery of nerve conduction in acute compression neuropathy. Experimental neuropathy with complete conduction block was produced by mechanical compression of the caudal nerves of 24 rats. Five days after compression, the compression site was injected with 0.2 mL Dexamethasone acetate (8 mg/mL suspension) in eight rats (group A), and 0.2 mL normal saline in another eight rats (group B). The remaining eight rats (group C) received no injection. Motor nerve conduction velocity (NCV) over the compressed segment, as well as amplitude of the evoked compound muscle action potential (CMAP) recorded from the segmental tail muscles, were measured before nerve compression and three times per week after nerve compression. The recovery rates of NCV of the caudal nerve were not significantly different among the three groups. The recovery rate of amplitude of CMAP in group A was significantly higher than that in groups B or C (p less than 0.01). However, there was no significant difference in recovery rate of the amplitude of CMAP between groups B and C. It is concluded that local steroid injection to the site of nerve compression may facilitate the recovery of nerve conduction block but not the recovery of demyelinative lesion.
本研究旨在探讨局部注射类固醇对急性压迫性神经病神经传导恢复的有效性。通过机械压迫24只大鼠的尾神经造成完全传导阻滞的实验性神经病。压迫5天后，8只大鼠（A组）在压迫部位注射0.2 mL醋酸地塞米松（8 mg/mL混悬液），另外8只大鼠（B组）注射0.2 mL生理盐水。其余8只大鼠（C组）不进行注射。在神经压迫前以及压迫后每周测量3次受压节段的运动神经传导速度（NCV）以及节段性尾肌记录的诱发性复合肌肉动作电位（CMAP）的波幅。三组尾神经NCV的恢复率无显著差异。A组CMAP波幅的恢复率显著高于B组或C组（p<0.01）。然而，B组和C组之间CMAP波幅的恢复率无显著差异。结论是，在神经压迫部位局部注射类固醇可能促进神经传导阻滞的恢复，但不能促进脱髓鞘病变的恢复。
