Khalilian Mohammad Reza, Sabri Mohammad Reza, Nikyar Abdolrasoul, Javanmard Shaghayegh Haghjooy
Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2011 Nov;16(11):1397-404.
Cardiac dysfunction is seen in many patients and could be evaluated with echocardiography and serum biomarkers. The aim of this study was evaluation of the relationship between echocardiographic findings and laboratory serum biomarkers in children with and without low cardiac output.
Thirty patients older than 1 month with and without low cardiac output were enrolled in this study. It composed of 13 patients with dilated cardiomyopathy (DCM), 7 with end stage renal disease (ESRD) and 10 who had a Fontan operation. Echocardiography was performed with emphasis on shortening fraction (SF) and ejection fraction (EF). Blood samples were collected for measurement of atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP) and alkaline phosphatase (Alk-P). Both echocardiographic findings and laboratory data were compared with control levels in twenty-seven normal children. Pearson correlation and regression analysis were conducted to evaluate the aforementioned associations.
The mean of ANP and hs-CRP in the case group was statistically higher than control group (p < 0.001). The mean of ANP and hs-CRP were different in all groups (p < 0.001). There was a reverse linear regression between the SF and ANP in the case group (r = -0.594, p < 0.001).
Determination of the plasma ANP and hs-CRP level may be helpful for decisions related to early diagnosis of patient with low cardiac output.
许多患者存在心脏功能障碍，可通过超声心动图和血清生物标志物进行评估。本研究的目的是评估有无低心输出量的儿童超声心动图检查结果与实验室血清生物标志物之间的关系。
本研究纳入了30例年龄大于1个月、有无低心输出量的患者。其中包括13例扩张型心肌病（DCM）患者、7例终末期肾病（ESRD）患者和10例接受Fontan手术的患者。进行超声心动图检查时重点关注缩短分数（SF）和射血分数（EF）。采集血样以测量心房利钠肽（ANP）、高敏C反应蛋白（hs-CRP）和碱性磷酸酶（Alk-P）。将超声心动图检查结果和实验室数据与27例正常儿童的对照水平进行比较。进行Pearson相关性和回归分析以评估上述关联。
病例组中ANP和hs-CRP的平均值在统计学上高于对照组（p < 0.001）。所有组中ANP和hs-CRP的平均值均不同（p < 0.001）。病例组中SF与ANP之间存在反向线性回归关系（r = -0.594，p < 0.001）。
测定血浆ANP和hs-CRP水平可能有助于做出与低心输出量患者早期诊断相关的决策。
